knockout

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knock·out

, knock-out (nok'out, nok'-out),
A genetically engineered organism in which the genome has been altered by site-directed recombination so that a gene is deleted.

knockout

(nŏk′out′)
adj. also knock-out (nŏk′out′)
Genetics Having a specific single gene inactivated or removed by genetic manipulation: knockout mice used in an experiment.
Experimental biology A genetically engineered mutant animal—e.g., Drosophila, mouse, fish, et al—in which a targeted gene has been inactivated to facilitate analysis of the knocked-out gene’s activity and function
Molecular medicine adjective Referring to the inactivation of a specific gene or genes noun A lab organism—e.g., yeast or mouse—in which a specific gene is altered, inactivating it and creating a model for a particular disease; in knockouts, an extracellular signal is converted to a functional intracellular change
Sports medicine KO The vanquishing of an opponent in a combat sport by bringing the opponent to the mat or ground. In boxing, this is defined as when the boxer is knocked down and cannot get up by the referee’s count of 10. A technical knockout (TKO) is one in which the referee or ringside doctor determines that the fighter is unable to defend himself or has sustained a serious injury, or when the fighter’s handlers throw in the towel
Vox populi Bombshell A woman who is stunningly beautiful

knock·out

, knock-out (nok'owt)
A genetically engineered organism in which the genome has been altered by site-directed recombination so that a gene is deleted.

knockout

see GENE DISRUPTION.
References in periodicals archive ?
Rodgers triumphed on a second-round technical knock out against South Doncaster's Courtney Boyle.
Abdurahimov beat Sokoudjou for three rounds until finally winning by Technical Knock Out (TKO).
Mark Dickinson won on a technical knock out against Brandon Churn (Oxers), Jack took a unanimous points decision over Codey Baxter (Fitness Factory ABC), and Burnside stopped Doncaster Plant's Tom Spencer in the second.
IRONICALLY, they are made by TKO, which stands for the boxing term Technical Knock Out.
Seven were won in the ring - Jay McGough on unanimous points at 125lb junior novice; Rikki Close unanimous at 132lb junior novice; Daniel English on a first-round knock out at 132lb open; Dylan Bousfield unanimous points 145lb junior novice; Paul Forster unanimous pts 175lb senior novice; Tony Curry technical knock out first round 181lb senior novice; and Simon Pendleton unanimous pts youth novice.

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