technetium Tc 99m sestamibi


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technetium Tc 99m sestamibi

A radioactive tracer consisting of technetium-99m linked to sestamibi. It is used to image blood flow to the heart muscle, esp. when combined with exercise or pharmacological “stress” tests. In a heart with normal blood flow, the isotope should be taken up uniformly throughout the heart muscle. Decreased uptake by regions of the heart occurs when coronary artery blood flow to those regions is blocked, e.g., by atherosclerotic plaque. Synonym: sestamibi
See also: technetium-99m
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Presence of concomitant thyroid nodules is very common and can lead to both false-negative and false positive results of technetium Tc 99m sestamibi scan.
During the past 10 years, nuclear medicine has been among the leaders in early detection of coronary artery disease (CAD), the leading cause of death in both men and women in the United States.[1] Recently there has been increased interest in using thallium Tl 201 and technetium Tc 99m sestamibi to assess patients with coronary artery disease.
Nuclear medicine scans using technetium Tc 99m sestamibi can help physicians determine which breast cancer patients will respond to chemotherapy and which patients won't, according to results of a phase II clinical trial published in the June issue of the Journal of Nuclear Medicine.