According to data from Allergan Inc., which makes Tazorac
(tazarotene gel), the normal, endogenous plasma level of retinoids is 6.6 ng/mL.
Topical retinoids such as all-trans-retinoic acid, (ATRA, Accutane), Differin, and Tazorac
, produce anti-inflammatory activities by downregulating TLR2 and CD14 mRNA, and this seems to be a specific action for TLR2, since there is very little measurable change in TLR4, for example.
salicylic acid, About 10 to 30 coal the tar, percent of Tazorac
people with (tazarotene) and psoriasis topical develop corticosteroids.
There are also new topical medications such as Dovonex (calcipotriene) ointment and Tazorac
(tazarotene) gel, which offer new treatment options.
Tazarotene is available in cream and gel formulations as Tazorac
, and both forms are rated pregnancy category X and are approved for the topical treatment of acne and plaque psoriasis.
Therefore, patients who use Retin-A, Renova, or newer topical retinoid preparations such as Tazorac
need to use sunscreens.
In June this year, the FDA approved Tazorac
gel (tazarotene) not only for the treatment of acne but for a miserable skin disorder more common to the older generation--psoriaris.
When my patients come in for an assessment, I feel bound to say, 'Look, we can do all these fancy procedures, lasers, and so forth, but if you use Retin-A for 6 months you're going to see a nice improvement, so maybe you should try that first.' It's quite common that I'll do that, although I prefer Tazorac
[tazarotene] for a number of reasons," said Dr.
"In fact, with Tazorac
[tazarotene, another newer-generation topical retinoid], because it's so irritating, we've actually realized that if you put moisturizer on before the Tazorac
, it actually slows the [drug's] absorption and softens the blow so you get less irritation," he noted.
The topical formulations are adapalene (a retinoid-like medication, also known as Differin), tretinoin (in varying strengths ranging from 0.01% to 0.1%, cream or gel, manufactured under such names as Retin-A or Avita), and tazarotene (tazorac
Physicians must choose among adapalene (Differin) 0.1%, which comes formulated as a gel, a cream, a solution, and as pledgets; tretinoin (Retin-A), which comes in four strengths between 0.01% and 0.1% as a cream and 0.01% and 0.025% as a gel; tretinoin micro (Retin-A Micro) gel, which comes in 0.04% and 0.1% strengths; and tazarotene (Tazorac
), which comes as a gel and as a cream in 0.05% and 0.1% strengths.
), a topical retinoid prodrug, is a second-line agent used as monotherapy or in combination.