Tamiflu


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oseltamivir phosphate

Tamiflu

Pharmacologic class: Viral neuro-aminidase inhibitor

Therapeutic class: Antiviral

Pregnancy risk category C

Action

Inhibits influenza virus neuraminidase, altering viral particle aggregation and decreasing viral release from infected cells

Availability

Capsules: 30 mg, 45 mg, 75 mg

Powder for oral suspension: 12 mg/ml

Indications and dosages

To prevent influenza type A

Adults and children older than age 13: 75 mg P.O. daily for 10 days, starting within 2 days of exposure; 75 mg P.O. daily during community outbreak of influenza for up to 6 weeks

Children ages 1 and older weighing more than 40 kg (88 lb): 75 mg P.O. daily for 10 days, starting within 2 days of exposure; continue dosing during community outbreak of influenza for up to 6 weeks

Children ages 1 and older weighing more than 23 kg up to 40 kg (more than 51 lb up to 88 lb): 60 mg P.O. daily for 10 days, starting within 2 days of exposure; continue dosing during community outbreak of influenza for up to 6 weeks

Children ages 1 and older weighing more than 15 kg up to 23 kg (33 lb up to 51 lb): 45 mg P.O. daily for 10 days, starting within 2 days of exposure; continue dosing during community outbreak of influenza for up to 6 weeks

Children ages 1 and older weighing 15 kg (33 lb) or less: 30 mg P.O. daily for 10 days, starting within 2 days of exposure; continue dosing during community outbreak of influenza for up to 6 weeks

Treatment of influenza type A

Adults and children older than age 13: 75 mg P.O. b.i.d. for 5 days, starting within 2 days of symptom onset

Children ages 1 and older who weigh more than 40 kg (88 lb): 75 mg P.O. b.i.d. for 5 days, starting within 2 days of symptom onset

Children ages 1 and older who weigh more than 23 kg and up to 40 kg (51 to 88 lb): 60 mg P.O. b.i.d. for 5 days, starting within 2 days of symptom onset

Children ages 1 year and older who weigh more than 15 kg and up to 23 kg (33 to 51 lb): 45 mg P.O. b.i.d. for 5 days, starting within 2 days of symptom onset

Children ages 1 and older who weigh less than 15 kg (33 lb): 30 mg P.O. b.i.d. for 5 days, starting within 2 days of symptom onset

Dosage adjustment

• Renal impairment

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:
• chronic cardiac or renal disease, respiratory disorders
• elderly patients
• pregnant or breastfeeding patients
• children younger than age 1 (safety and efficacy not established).

Administration

• For flu treatment, give first dose at onset of symptoms. For flu prevention, give within 2 days of exposure.

Adverse reactions

CNS: headache, dizziness, fatigue, insomnia, unusual behavior, confusion

GI: nausea, vomiting, diarrhea

Respiratory: cough, bronchitis

Skin: epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome

Other: hypersensitivity reactions (including anaphylaxis)

Interactions

None significant

Patient monitoring

Monitor patient closely for allergic reaction or severe rash; discontinue drug immediately if these occur.
• Closely monitor patient for unusual behavior or confusion.
• Monitor respiratory status. Watch for signs and symptoms of secondary infection.

Patient teaching

• Instruct patient to take as soon as flu symptoms occur and to complete entire course of therapy.
• Advise patient to take with food or milk to minimize GI irritation.
• Tell patient to prepare oral solution by adding water to powder and shaking well.

Instruct patient or caregiver to discontinue drug and seek immediate medical attention if rash or swelling of lips, face, or throat occurs
• Instruct patient or caregiver to report change in behavior.
• Caution patient not to share drug with others, even if they have similar symptoms.
• Instruct patient to consult prescriber before taking other drugs.
• As appropriate, review all other significant adverse reactions.

Tamiflu

(tăm′ə-flo͞o′)
A trademark for the phosphate form of the drug oseltamivir.

oseltamivir

An antiviral ingested as a prodrug, which is used to manage influenza A or B. A Cochrane review published in 2009 found no clear benefit for oseltamivir if taken after the first 24 hours.
 
Adverse events
Nausea, vomiting, diarrhoea, abdominal pain, and headache.

Tamiflu®

Oseltamivir Infectious disease An oral neuraminidase inhibitor used for influenza A and B

Tamiflu

A brand name for OSELTAMIVIR.
References in periodicals archive ?
Tamiflu is an antiviral medication prescribed to prevent the symptoms of influenza A and influenza B within 48 hours of onset of symptoms.
But few have questioned the use of Tamiflu in conjunction with the flu shot.
Tamiflu is now the only approved prescription oral antiviral medicine to treat infants from two weeks old and adults.
The antiviral drugs Relenza and Tamiflu, which target the neuraminidase (NA) enzyme, successfully treated the infection but widespread use of these drugs has led to a series of mutations in NA that reduce the drugs' effectiveness.
They found Tamiflu "did not reduce influenza-related lower respiratory tract complications" but did induce nausea.
Tamiflu is available in 75-mg capsules for adults and 30- and 45-mg capsules for children.
The agency purchased the supposed generic Tamiflu from an online pharmacy that is no longer operational, but the fake drug is still being sold through other Internet sites and without a prescription.
Her family suspected she may have died so suddenly because of an adverse reaction to her Tamiflu medication.
Yesterday, the hearing was told that although Tamiflu was ineffective in treating patients suffering from severe cases of swine flu in hospital, it did help those less seriously ill.
I even hinted that garlic might be better than Tamiflu for the flus running rampant around here in 2009.
If the behavior of the seasonal form of H1N1 influenza virus is any indication, scientists say that chances are good that most strains of the pandemic H1N1 flu virus will become resistant to Tamiflu, the main drug stockpiled for use against it.
A GIRL who suffered a severe allergic reaction after taking swine flu treatment Tamiflu never had the virus, tests revealed.