Also found in: Dictionary, Thesaurus, Encyclopedia.
a severe form of acatalasia occurring in Japan.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
Takahara's disease(tăk′ə-hăr′əz, tä′kə-hä′rəz)
Acatalasemia, especially when oral sores and gangrene are present.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
acatalasiaAn autosomal dominant MIM 115500 condition of early onset first described in the Japanese, caused by a deficiency in tissue and RBC catalase, the enzyme that reduces H2O2; as H2O2 accumulates, malignant alveolar pyorrhea, and oral gangrene ensue, requiring removal of all teeth.
Acatalasia is caused by a mutation of CAT, located on chromosome 11p13, which encodes catalase, an anti-oxidant enzyme that converts hydrogen peroxide into water and oxygen.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.