Takahara's disease


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Related to Takahara's disease: acatalasemia, Acatalasia

Takahara's disease

 [tah-kah-hah´rahz]
a severe form of acatalasia occurring in Japan.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

Takahara's disease

(tăk′ə-hăr′əz, tä′kə-hä′rəz)
n.
Acatalasemia, especially when oral sores and gangrene are present.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

acatalasia

An autosomal dominant MIM 115500 condition of early onset first described in the Japanese, caused by a deficiency in tissue and RBC catalase, the enzyme that reduces H2O2; as H2O2 accumulates, malignant alveolar pyorrhea, and oral gangrene ensue, requiring removal of all teeth.
 
Molecular pathology
Acatalasia is caused by a mutation of CAT, located on chromosome 11p13, which encodes catalase, an anti-oxidant enzyme that converts hydrogen peroxide into water and oxygen.
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