The study's key finding noted that Tagamet
has been known to interfere with the body's ability to process the sex hormone estrogen.
I continued to use moisturizing creams and lotions, Opticrom eye drops, OTC eye drops, hydrocortisone creams, Periactin, Tagamet
and antihistamines, and of course ZOLOFT!
The percentages in the example are loosely based on the APA between SmithKline Beecham and the IRS for Tagamet
. The resale price method was used, and the APA was based on an outbound transfer price (see Exhibit 2 for a glossary of terms).
These agents, used for heartburn and GERD, include the histamine [H.sub.2] antagonists cimetidine (Tagamet
), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac) and the proton pump inhibitors esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (Aciphex).
Alka-Seltzer, Maalox, Tums, and Rolaids can interfere with the stomach's absorption of Agenerase, Crixivan, Rescriptor, and Reyataz, while Axid, Pepcid, Tagamet
, and Zantac should be entirely avoided by those taking Crixivan, Rescriptor, and Reyataz.
can cause an increase in some liver enzymes, especially if taken in large amounts for a long period of time.
Another kind of medicine to reduce stomach acidity, H2-receptor antagonists (such as Zantac, Tagamet
, etc.) might also lower atazanavir levels; a study to find out is now ongoing.
Later, studies at the University of Connecticut, Farmington, determined that about one-third of patients also respond to cimetidine (Tagamet
), and in those lucky few, the drug prompts remission.
The story of stomach-acid-blocking drugs such as Tagamet
and Zantac illustrates how drugs save money by keeping patients out of the hospital.
Michael Gorback recalls that several years ago, when he was on the faculty of Duke Medical School, Smith Kline asked him to do a presentation on an antacid they were marketing called Tagamet
. According to Gorback, for the occasion the manufacturer "pulled together a panel of myself, a Harvard med school professor, and a chairman from one of the University of California medical schools."
Brand-name prescription drugs offered by pharmaceutical companies are often many times the price of generic treatments - generic ulcer drug cimetidine cost pounds 5 before it was made unavailable, but SmithKline Beecham's brand equivalent, Tagamet
, costs the NHS pounds 22.62.
When administered concomitantly with probenecid (Benemid) or cimetidine (Tagamet
), monitor for renal toxicity.