The percentages in the example are loosely based on the APA between SmithKline Beecham and the IRS for Tagamet
When Gorback describes the Tagamet
event as "one of the most disgusting experiences of my career" he's talking about the ethics on the dais.
In addition to simply assessing the existing antacid market, the team evaluated prior OTC H2 switches, such as Pepcid AC and Tagamet
HB, as well as recent non-antacid OTC switches, such as Procter & Gamble's Aleve.
News study, there are many others, including such commonly prescribed medications as Tagamet
, Coumadin, Lanoxin, Tegretol, and Dilantin, which can interact with other medicine.
For example, today consumers can buy Tagamet
HB or Pepcid AC--drugs commonly used to treat heartburn--off a drugstore shelf, but for many years only a doctor, acting as a "learned intermediary," could prescribe them.
He discourages treating ulcers for years with palliative, symptom-alleviating antacids like Tagamet
The introduction of Tagamet
in the United States in 1977 represented both a revolution in ulcer therapy and the beginning of an important new industry.
Marshall is trying to spread the word that more costly treatments such as Zantac and Tagamet
are only maintaining, not curing, ulcer patients.
An example is SmithKline Beecham and its Tagamet
product for treating ulcers, which afforded it a multiple well above the average for the pharmaceutical group at the time the drug was introduced.
People who took histamine 2 receptor antagonists (H2RAs) like Tagamet
, Zantac, Pepcid, and Axid for at least two years had a 25 percent higher risk of B-12 deficiency than those who didn't take H2RAs.
More serious cases of GERD may require stronger medications, the most common of which are histamine type 2 receptor antagonists (H2-hlockers), such as prescription-strength Axid, Pepcid, Tagamet
and Zantac, and proton pump inhibitors (PPIs), such as Prevacid, Prilosec, Nexium, and Aciphex.
The deal, which includes such brands as Tagamet
, Sominex and Gaviscon, is expected to be completed in the first half of this year.