tachykinin

(redirected from Tachykinins)

tach·y·ki·nin

(tak'i-kī'nin),
Any member of a group of polypeptides, widely scattered in vertebrate and invertebrate tissues, which have in common four of the five terminal amino acids: Phe-Xaa-Gly-Leu-Met-NH2; pharmacologically, they all cause hypotension in mammals, contraction of gut and bladder smooth muscle, and secretion of saliva.
[G. tachys, swift, + kineō, to move, + -in]

tachykinin

/tachy·ki·nin/ (-ki´nin) any of a family of peptides structurally and functionally similar to substance P; all are potent, rapidly acting secretagogues and cause smooth muscle contraction and vasodilation.

tachykinin

tachykinin

(tăk″kī′nĭn) [″ + ″],

TK

Any of a large family of peptides that function as neurotransmitters in the central and peripheral nervous systems. They have extraneuronal activity in other body tissues. Their diverse biological actions are mediated through cellular G proteins.
Mentioned in ?
References in periodicals archive ?
Acetylcholine and tachykinins are involved in the excitatory transmission (3,5,32,33).
Tachykinins are neuropeptides or proteins expressed throughout the nervous and immune systems, where they participate in many cellular and physiological processes and have been linked to multiple diseases, including chronic inflammation, cancer, infection and affective and addictive disorders.
Serotonin, tachykinins, prostaglandins and histamine are the main secretions of carcinoids.
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.
Cys-LTs amplify action potential-dependent release of tachykinins such as substance P from airway afferent nerve fibers and LTRAs inhibit such release.
Tachykinins (TACs) are characterized by pharmacological similarity to their endogenous inflammatory mediator, bradykinin, yet TACs are not of similar structure to that of bradykinin.
The ventral tegmental area as a putative target for tachykinins in cardiovascular regulation.
7] Poor gut contractility and slow intestinal transit times in ICU patients also involve inhibitory neurotransmitters such as nitric oxide and vasoactive intestinal peptide, as well as tachykinins such as substance P and the neurokinin family.
4) Additional brain stress response systems involve the signalingmolecules norepinephrine, neuropeptide y, tachykinins, anddynorphins.
PGE2 stimulates the release of tachykinins, which stimulate neurokinin receptors on afferent nerves and the detrusor smooth muscle and as a result promote detrusor contraction (Andersson & Hedlund, 2002; Verhamme et al.
Primary afferent tachykinins are required to experience moderate to intense pain.
One important mechanism is by an increase of tachykinins in patient blood, possibly mediated by neurotrophins produced in response to viral infection.