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Any member of a group of polypeptides, widely scattered in vertebrate and invertebrate tissues, which have in common four of the five terminal amino acids: Phe-Xaa-Gly-Leu-Met-NH2; pharmacologically, they all cause hypotension in mammals, contraction of gut and bladder smooth muscle, and secretion of saliva.
[G. tachys, swift, + kineō, to move, + -in]
Farlex Partner Medical Dictionary © Farlex 2012


(tăk″kī′nĭn) [″ + ″],


Any of a large family of peptides that function as neurotransmitters in the central and peripheral nervous systems. They have extraneuronal activity in other body tissues. Their diverse biological actions are mediated through cellular G proteins.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Rameshwar, "Tachykinins in the emerging immune system: relevance to bone marrow homeostasis and maintenance of hematopoietic stem cells," Frontiers in Bioscience, vol.
Hellstrom, "Tachykinins influence interdigestive rhythm and contractile strength of human small intestine," Digestive Diseases and Sciences, vol.
Acetylcholine and tachykinins are involved in the excitatory transmission (3,5,32,33).
mRNA expression of tachykinins and tachykinin receptors in different human tissues.
Tachykinins are neuropeptides or proteins expressed throughout the nervous and immune systems, where they participate in many cellular and physiological processes and have been linked to multiple diseases, including chronic inflammation, cancer, infection and affective and addictive disorders.
Serotonin, tachykinins, prostaglandins and histamine are the main secretions of carcinoids.
Marrocco et al., "Role of tachykinins in the bronchoconstriction induced by HCl intraesophageal instillation in the rabbit," Life Sciences, vol.
Tamei et al., "A peptidase in human platelets that deamidates tachykinins: probable identity with the lysosomal 'protective protein'," Journal of Biological Chemistry, vol.
Murillo, "Contractile effect of tachykinins on rabbit small intestine," Acta Pharmacologica Sinica, vol.
Nieto et al., "Tachykinins and tachykinin receptors: structure and activity relationships," Current Medicinal Chemistry, vol.
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.
Cys-LTs amplify action potential-dependent release of tachykinins such as substance P from airway afferent nerve fibers and LTRAs inhibit such release.