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trademark for preparations of chlorotrianisene, a synthetic estrogen used for palliative treatment of prostate cancer and for replacement therapy.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


An ADAMs family protein encoded by ADAM17 on chromosome 2p25, which acts as a tumour necrosis factor-alpha converting enzyme (TACE). It binds mitotic arrest-deficient 2 protein, and plays a key role in activating Notch signalling, resulting in the proteolytic release of cell-surface proteins, including p75 TNF-receptor, IL-1 receptor type II, p55 TNF-receptor, TGF-alpha, L-selectin, growth hormone receptor, MUC1 and amyloid precursor protein (APP).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

transcatheter arterial chemoembolization



A technique for destroying tumors in which a tube is guided into the arterial blood supply of the tumor and drugs, fragments of muscle, or synthetic spheres are introduced to obstruct the artery. It is used to treat liver cancers that cannot be removed surgically.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
This report provides comprehensive information on the current therapeutic developmental pipeline of Tacere Therapeutics, Inc.'s, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
30 October 2012 - Australian biotechnology company Benitec Biopharma Limited (ASX:BLT) said today it had completed the purchase of US-based RNA interference (RNAi) therapeutics company Tacere Therapeutics Inc, which it had announced earlier this month.
At present, some 170m people are chronically infected with hepatitis C and 350,000 deaths from HCV-related liver disease are registered each year, according to the World Health Organisation, Benitec said.Country: USASector: BiotechnologyTarget: Tacere Therapeutics IncBuyer: Benitec Biopharma LimitedDeal size in USD: 1.5mType: Corporate acquisitionFinancing: All-stockStatus: Closed
Radu Tudor, Romania's Anti-terrorist Brigade extends co-operation in fight against terror, Jane's Intelligence Review, January 01, 2002; Darius Martinescu, SEAL-ul Romanesc se Antreneaza in Tacere. Romania Libera, October 13, 2008.
4 ce impunea judecatorului obligatia de a judeca si in conditiile in care legea pastra tacere sau in caz de obscuritate sau insuficienta a ei.
Benitec is licensing its ddRNAi platform technology for specific applications to biopharmaceutical companies, including US-based Tacere Therapeutics, Inc., who have exclusively licensed Benitec's technology for development of a ddRNAi-based molecule for treating hepatitis C viral infections, with successful pre-clinical results.
The Rest Is Silence / Restul e tacere. Romania, 2008
It is to this passage that Longinus refers in the ninth chapter of the treatise On the Sublime, when he sees in this condition the "echo of a high sensibility." Pliny the Younger affirms that silence was part of the teaching of rhetoric: "At times it is no less eloquent to be silent than to speak" (Letters VII, 6, 7) ("Non minus interdum oratorium est tacere quam dicere").