[EC.sub.50] values of favipiravir in cytopathic effect (CPE) assay using Vero cells were 0.79-0.94 [micro]g/mL for Junin virus, Pichinde virus (PICV) and Tacaribe virus
. In the virus yield reduction assay with Vero cells on days 3 and 5 post-infection, the 90% effective concentration ([EC.sub.90]) values against Lassa virus (LASV) were 1.7 and 11.1 [micro]g/mL, respectively.
Tacaribe serocomplex viruses (family Arenaviridae, genus Arenavirus) comprise Bear Canyon virus, Tamiami virus, and Whitewater Arroyo virus in the United States; Tacaribe virus
(TCRV) on Trinidad; Chapare virus (CHPV) and Machupo virus (MACV) in Bolivia; Guanarito virus (GTOV) in Venezuela; Junin virus (JUNV) in Argentina; Sabia virus (SABV) in Brazil; and 9 other species (1).
Central African (Nile grass rat) Republic Classic New World Arenaviruses Junin virus Calomys masculinus Argentina (corn mouse), Akodon azarae (grass field mouse), Bolomys obscurus (dark field mouse) Machupo virus Calomys callosus Bolivia (vesper mouse) Guanarito virus Sigmodon alstoni Venezuela (cane mouse) Sabia virus Unknown Brazil Selected Less Common New World Arenaviruses Tacaribe virus
, a new agent isolated from Artibeus bats and mosquitoes in Trinidad, West Indies.
Louis encephalitis virus, Rocio virus, Ilheus virus, West Nile virus, Venezuelan equine encephalitis virus, eastern equine encephalitis virus, Mayaro virus, Trocara virus, Oropouche virus, Caraparu virus, Murtucu virus, Guaroa virus, hantavirus, Machupo virus, and Tacaribe virus
; after the cardiovirus isolation, EMCV antibody also was used.
Arenaviruses can be divided phylogenetically, serologically, and geographically into two major complexes: the Old World complex (e.g., Lassa virus, lymphocytic choriomeningitis virus [LCMV]) and the New World complex (e.g., Tacaribe virus
, Junin virus, Machupo virus) (11).