thiazolidinedione

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gli·ta·zone

(glit-ah'zōn),
Shorthand term for a class of oral hypoglycemics that have glitazone as a component in their names.
Synonym(s): thiazolidinedione

thiazolidinedione

(thī′ə-zō′lĭ-dēn′dĭ-ōn′)
n.
Any of a class of drugs that decrease insulin resistance and are used to treat type 2 diabetes.

thiazolidinedione

Glitazone, TZD Endocrinology A class of oral antidiabetic agents that inhibit tyrosine kinase, ↓ insulin resistance and correct hyperglycemia, hyperinsulinemia, hypertriglyceridemia Adverse effects Hepatic dysfunction. See Troglitazone, Tyrosine kinase inhibitor.

thiazolidinedione

(thī′ă-zŏ″lĭ-dēn-dī-ŏn)
A class of oral hypoglycemic agents that lowers blood sugars by reducing insulin resistance (improving tissue sensitivity to the effects of insulin) in fat and muscle, as well as the liver. A commonly used agent in this class is pioglitazone.

CAUTION!

Side effects of medications in this class include increased fluid retention, fractures, heart failure, liver injury, and weight gain.
References in periodicals archive ?
In the diabetes study, Prentice and colleagues specified two populations for falsification testing that were closely related to the study population but not subject to treatment by SU or TZD (Prentice et al.
Major finding: No increased risk of major cardiovascular events associated with rosiglitazone was identified in a study of patients with type 2 diabetes and coronary artery disease, including a nonsignificant lower risk (23%) of MI among those treated with the thiazolidinedione (TZD) compared with those who had not received a TZD.
The animals in the control group were fed with a basic diet, whereas those in the test group were fed with a basic diet supplemented with 15 mg/kg TZD.
Based on the side effect story of TZDs, thus discovery of the other class drugs that selective into PPAR[gamma] and PPAR[alpha] agonist increases to reduce the risk of the fatal side effect of the drugs.
Patients and doctors who find success with rosiglitazone may want to stay within the TZD class and switch to pioglitazone, but other alternatives exist.
Brillon says it isn't clear why TZDs increase heart risks, but notes that one possible mechanism could be found in their effects on cholesterol and triglycerides (blood fats).
Higher TZD doses were associated with a statistically significant 42% increase in the odds of fractures for women aged 50 years and older, but not for women under the age of 50 years or for men (J.
When analyzed by gender, women taking a TZD were 55 percent more likely to experience a bone fracture than women not on a TZD, while men had a 26 percent higher likelihood of fracture.
Daha Onceleri TZD, sadece New York Heart Association (NYHA) evre III ve IV konjestif kalp yetersizliginde Onerilmemekteydi.
TZD is an interagency partnership led by the Minnesota Department of Public Safety and Department of Transportation (Mn/DOT), and it cooperates with the State Patrol, FHWA, Minnesota county engineers, the University of Minnesota's Center for Transportation Studies, and other State and local agencies.
So what should you do if you've been taking a TZD such as rosiglitazone for type 2 diabetes?