TXA2


Also found in: Acronyms.

thromboxane A2

(throm-bok'san),

TXA2

An unstable compound synthesized in platelets and other cells from a prostaglandin, PGH2. It acts to aggregate platelets, is a potent vasoconstrictor, and mediates inflammation.
See: eicosanoid; prostaglandin; prostanoids
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The free 7-OH group in the A ring might potentially affect flavonoids by binding to TxA2 receptor (Cavia-Saiz et al.
The urinary PGD2 (Figure 1(b)), TXB2 (stable metabolite of TXA2) (Figure 1(c)), and 6-keto-PGF1[alpha] (stable metabolite of PGI2) (Figure 1(d)) were all remarkably increased in the db/db mice, which was unaffected by Rosi administration.
Furthermore, microfluidic devices recreate the progression of signaling and thrombotic pathways as they progress from a surface trigger, i.e., collagen and/or thrombin produced at the wall (14, 19), to secondary aggregation processes driven by ADP and TXA2.
A COX-2 resulta na formacao de prostaciclinas promovendo efeitos antitromboticos, vasodilatacao e reducao da agregacao e adesao plaquetaria, porem recentemente se identificou a COX-2 em amostras de placas ateromatosas coronarianas e carotideas, com isso os inibidores da COX-2 poderiam afetar o equilibrio entre TXA2 e prostaciclinas levando ao aumento de eventos tromboticos e cardiovasculares.
La activacion plaquetaria induce la sintesis y secrecion de sustancias que estimulan la agregacion de otras plaquetas circulantes; en este sentido, el tromboxano A2 (TXA2) y el adenosin-difosfato (ADP) actuan de manera sinergica.
Aspirin selectively and irreversibly acetylates the serine residue in cyclooxygenase-1 (COX-1) present in platelet, thereby blocking the synthesis of prothrombotic thromboxane A2 (TXA2).
Large platelets are more reactive, produce more prothrombotic factors, and show greater aggregation to adenosine diphosphate (ADP), collagen or adrenaline and secrete more thromboxane A2 (TxA2).1,2 Increased platelet size has been reported in patients with vascular risk factors such as diabetes mellitus (DM), hypercholesterolaemia, myocardial infarction, ischaemic stroke and smoking.3
Meloxicam acts by inhibiting the platelet TxA2 production also preferentially cycloxygenese (Cox-2) enzyme thereby exerting potent anti-inflamatory and analgesic effects (Tripati Loc., cited).
Litt, "Menstrual-PGF2a, PGE2 and TXA2 in normal and dysmenorrheic women and their temporal relationship to dysmenorrhea," Prostaglandins, vol.
Os AINEs COX-2 seletivos reduzem a formacao de PGI2 pelas celulas endoteliais, consequentemente rompendo o equilibrio entre TXA2 e PGI2 e potencialmente favorecendo eventos protromboticos cardiovasculares (FRESNO et al., 2008).
Aut hors suggest that this may be related to PAF rather than TXA2 (11).
Effects of PGI2 and TxA2 analogs and inhibitors in orthodontic tooth movement.