TWSG1

TWSG1

A gene on chromosome 18p11.3 that encodes a protein thought to be involved in dorsoventral axis formation, which both:
(1) Antagonises bone morphogenetic protein (BMP)-signalling by forming ternary complexes with chordin and BMPs, thereby preventing BMPs from binding to their receptors; and
(2) Acts in a pro-BMP fashion by cleaving and degrading chordin, releasing BMPs from ternary complexes.
References in periodicals archive ?
Correlations between the expression of TWSG1 expression and serum iron parameters and serum hepcidin concentrations have not yet been determined in humans.
GDF15 and TWSG1 are both BMP antagonists produced by erythroblasts and putative components of the erythroid regulator that can inhibit hepcidin expression in vitro.
Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.