TUT1

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TUT1

A gene on chromosome 11q12.2 that encodes an enzyme which functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase, adding and removing nucleotides from the 3' end of small nuclear RNAs and specific mRNAs; it may also may control gene expression and cell proliferation.

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4] Nonstandard abbreviations: PSA, prostate specific antigen; miRNA, microRNA; primiRNA, primary miRNA; pre-miRNA, precursor miRNA; dsRNA, double stranded RNA; DGCR8, dsRNA-binding protein of DiGeorge Syndrome Critical Region Gene 8; EXP5, exportin 5; RISC, RNA induced silencing complex; AGO, argonaute protein; TUTase, terminal uridylyl transferase; ac-pre-miR-451, AGO-cleaved pre-miR-451; PARN, poly(A)-specific ribonuclease; TUT, terminal uridyl transferase; [m.

In the TUTase dependent pathway, pre-miRNAs with a shorter 3" overhang such as the members of the let-7 family undergo monouridylation by TUTases, TUT2, TUT4, and TUT7 for efficient Dicer processing.