Lin28 recruits the TUTase
Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells.
Gregory, "Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells," Nature Structural & Molecular Biology, vol.
Upon binding to pre-let-7, LIN28A or LIN28B recruits TUTase, which causes oligouridylation resulting in the degradation of pre-let-7.
Alternatively, a small number of miRNAs are processed through the noncanonical pathways of miRNA biogenesis, which involve the Dicer-independent, terminal uridylyl transferase (TUTase
)-dependent, and Drosha DGCR8-independent miRNA biogenesis pathways (5) (Fig.
In the cytoplasm, Lin-28 is able to inhibit Dicer-mediated cleavage of the pre-let-7 family member  by recruiting a terminal uridylyl transferase (TUTase
) to the precursor.