TUT1

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TUT1

A gene on chromosome 11q12.2 that encodes an enzyme which functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase, adding and removing nucleotides from the 3' end of small nuclear RNAs and specific mRNAs; it may also may control gene expression and cell proliferation.

References in periodicals archive ?

Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells.

Antiproliferative effect of urolithin A, the ellagic acidderived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis

Gregory, "Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells," Nature Structural & Molecular Biology, vol.

Upon binding to pre-let-7, LIN28A or LIN28B recruits TUTase, which causes oligouridylation resulting in the degradation of pre-let-7.

The Molecular Basis and Therapeutic Potential of Let-7 MicroRNAs against Colorectal Cancer

Alternatively, a small number of miRNAs are processed through the noncanonical pathways of miRNA biogenesis, which involve the Dicer-independent, terminal uridylyl transferase (TUTase)-dependent, and Drosha DGCR8-independent miRNA biogenesis pathways (5) (Fig.

MicroRNA Theranostics in Prostate Cancer Precision Medicine

In the cytoplasm, Lin-28 is able to inhibit Dicer-mediated cleavage of the pre-let-7 family member [40] by recruiting a terminal uridylyl transferase (TUTase) to the precursor.