TUT1

(redirected from TUTase)

TUT1

A gene on chromosome 11q12.2 that encodes an enzyme which functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase, adding and removing nucleotides from the 3' end of small nuclear RNAs and specific mRNAs; it may also may control gene expression and cell proliferation.
References in periodicals archive ?
Gregory, "Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells," Nature Structural & Molecular Biology, vol.
Upon binding to pre-let-7, LIN28A or LIN28B recruits TUTase, which causes oligouridylation resulting in the degradation of pre-let-7.
Alternatively, a small number of miRNAs are processed through the noncanonical pathways of miRNA biogenesis, which involve the Dicer-independent, terminal uridylyl transferase (TUTase)-dependent, and Drosha DGCR8-independent miRNA biogenesis pathways (5) (Fig.
In the cytoplasm, Lin-28 is able to inhibit Dicer-mediated cleavage of the pre-let-7 family member [40] by recruiting a terminal uridylyl transferase (TUTase) to the precursor.