TUBB3

TUBB3

A gene on chromosome 16q24.3 that encodes a beta tubulin, which is a major constituent of microtubules. TUBB3 plays a key role in proper axon guidance and maintenance.

Molecular pathology
Defects of TUBB3 cause congenital fibrosis of extraocular muscles type 3A, and cortical dysplasia complex with other brain malformations.
References in periodicals archive ?
All mutation subtypes presented equally frequent expression of MGMT, SPARC, TOP2A, TOPO1, TS, TUBB3 and RRM1, suggestive of multiple chemoresistance pathways.
7 percent) of 1048 patients through a combination of overexpression of ABCB1 and either high expression of TUBB3 or low expression of topoisomerase 2A (TOPA2A), suggesting resistance to taxanes and anthracyclines.
Immunohistochemistry and gene amplification identified low ERCC1 (64%), low TUBB3 (74%) and high TOPO1 (51%) as targets for platinum-based therapies, taxanes, and topotecan, respectively.
Of the 21 IHCs, 15 will be available immediately and include: PD1, PD-L1, MGMT, MET, TOP1, PTEN, AR, CAIX, ER, HER2, IDO, PR, TRKA, TRKB and TUBB3.