Analysis of SPARC and TUBB3
as predictors for prognosis in esophageal squamous cell carcinoma receiving nab-paclitaxel plus cisplatin neoadjuvant chemotherapy: a prospective study.
Combined analysis of rearrangement of ALK, ROS1, somatic mutation of EGFR, KRAS, BRAF, PIK3CA, and mRNA expression of ERCC1, TYMS, RRM1, TUBB3
, EGFR in patients with non-small cell lung cancer and their clinical significance.
Literature reviews revealed pathogenic variants in the TUBBI (Tubulin Beta 1 Class VI), TUBBI (Tubulin Beta 2 Class II), TUBB3
(Tubulin Beta 3 Class III) (3), TUKLS (Tukel syndrome) (6), KIF21A (Kinesin Family Member 21 A) (8), COL2A1 (Collagen Type XXV Alpha 1 Chain) (7) and PHOX2A (Paired Like Homeobox 2a) (2) genes in different types of CFEOM.
gene is the most increased gene on our list of genes (Figure 1(b)) from our own patient materials.
The expression of RPC (PAX6 and NES), RGC (ATOH7 and TUBB3
), photoreceptor (CRX, NRL, RHO, and RCVRN), and Notch signaling (NOTCH1 and HES1) markers was evaluated by the Quanti-Nova SYBR Green PCR Kit (Qiagen) with specific primers (Supplementary Table 2) in a LightCycler480 (Roche).
While other proteins (GSK3B, POU5F1, MAPK14, CREB1, SOX2, KLF4, PRKACA, MAPK10, STAT1, ACTB, TUBB3
, MYC, GAPDH, AKT1, and CTNNB1) are related with process of aging, neuronal diseases, cardiovascular diseases, abnormal brain development, mental retardation, schizophrenia, and mycobacterial and viral infections [60-62].
High AR expression could present as a potential therapeutic target for DSRCT while taxanes may be more effective in Ewing sarcoma compared to DSRCT based on TUBB3
Three days after SCI (a complete transection at T9), thoracic PNs showed an upregulated expression of a suite of regeneration-associated genes (including Actb, Atf3, Cd44, Crem, Ctsb, Gap43, Hsbp1, Jun, Pacap, Sox11, Stat3, and Tubb3
Wu et al., "Human TUBB3
mutations perturb microtubule dynamics, kinesin interactions, and axon guidance," Cell, vol.
RT PCR versus immunohistochemistry for correlation and quantification of ERCC1, BRCA1, TUBB3
and RRM1 in NSCLC.
The network also shows a correlation between berberine-targeted proteins and neuronal differentiation markers (MAP2 (mtap2); and Tub III (Tubb3
) accompanied with the signalling proteins involved in regulation of cell cycle, apoptosis, PI3K/AKT, Ras-Raf-ERK1/2MAPK, MMPs and EMT markers.
[sup] confirmed ovarian cancer patients with low expression of targets (TUBB3
) of antimicrotubular drugs had obviously longer survival period than patients with high expression of TUBB3
by TaqMan probe, suggesting miR-200c can increase the sensitivity of ovarian cancer tissues to chemotherapy drug taxol via target regulation on TUBB3