TUBA4A

A gene on chromosome 2q35 that encodes an alpha tubulin, which combines with a beta tubulin to form microtubules, acting as a scaffold to determine cell shape and providing a matrix for cell organelle and vesicle movement via motor proteins.

References in periodicals archive ?

Fallini et al., "Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS," Neuron, vol.

Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNF[alpha]

Van Mossevelde et al., "Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients," Neurobiology of Aging, vol.

MNRR1, a Biorganellar Regulator of Mitochondria

The second DEP cluster was the tubulin complex, in which TUBA4A can be targeted by vincristine to blunt mitotic chromosomal separation (Figure 2(d)).

Identification of Pharmacologically Tractable Protein Complexes in Cancer Using the R-Based Network Clustering and Visualization Program MCODER

Because of missing data from the public Agilent data set, the Agilent evaluations were performed with a 47-gene classifier, rather than a 52-gene panel with exclusion of the following genes: CIB1, FOXH1, LIFE, NCAM1 (PCAM1), and TUBA4A (TUBA1).

Validation of the Lung Subtyping Panel in Multiple Fresh-Frozen and Formalin-Fixed, Paraffin-Embedded Lung Tumor Gene Expression Data Sets

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