TTP-HUS

TTP-HUS

Abbreviation for thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. See: thrombotic thrombocytopenic purpura, hemolytic uremic syndrome.

TTP-HUS

The combination of thrombotic thrombocytopenic purpura–TTP and hemolytic-uremic syndrome–HUS, polar expressions of the same disease defined by a pentad of TTP features: Thrombocytopenia, microangiopathic hemolytic anemia, neurologic defects, fever, renal disease Clinical Abrupt onset in children after a viral URI; may be associated with a verotoxin in E coli-induced gastroenteritis; it may occur in pregnancy, at parturition, or during chemotherapy; spontaneously resolving renal failure–RF occurs in 60%–10% progress to chronic RF; RF is more common in E coli O157:H7 infections, which are linked to 16% of cases with HUS Lab Reticulocytosis, ↑ BR, ↑ FDPs without DIC, ↓ haptoglobin Management Most resolve spontaneously, others require high-dose corticosteroids Prognosis with prednisone and plasma exchange, 91% survival
References in periodicals archive ?
Oklahoma TTP-HUS registry data was analysed by George et al12, table shows a comparison of our study population with George's study.
This case highlights how Non O157:H7 E.coli ESBL induced sepsis could produce a classical pentad of TTP-HUS. With the management of HUS being mainly supportive and little evidence about the positive role of antibiotics1 and PLEX,2 E.coli ESBL sepsis needs aggressive management with appropriate antibiotics.
Possibility of non H7:O157 E.coli ESBL producing a TTP-HUS picture should be considered in patients presenting with classic TTP pentad.
The incidence of acquired TTP is approximately three cases per one million adults per year, based on data from the Oklahoma TTP-HUS Registry.
Terrell, "The Oklahoma Thrombotic Thrombocytopenic Purpura-Hemolytic Uremic Syndrome (TTP-HUS) Registry: A Community Perspective of Patients with Clinically Diagnosed TTP-HUS," Seminars in Hematology, vol.
showed that 71% of patients clinically diagnosed with TTP had severe ADAMTS13 deficiency.20 In Oklahoma registry data of 301 patients 13% of all patients, and 33% of patients with idiopathic TTP-HUS, had very severe ADAMTS-13 deficiency (<5% activity).12
The spectrum was significantly different from other reports, such as in the Oklahoma TTP-HUS Registry from 1995 to 2009; idiopathic TTP-HUS plus bloody diarrhea prodromal HUS accounted for 46.6% of all the 283 patients [20], and in Japan Nara Medical University TMA registry from 1998 to 2008, congenital and idiopathic TTP-HUS plus E.
A number of chemotherapeutic agents have been proved to be associated with TTP-HUS, including gemcitabine, cisplatin, doxorubicin, oxaliplatin, and mitomycin C.
(4) Seventeen TTP-HUS patients with platelet counts < 20,000 underwent 18 central line placements.
Thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) is among these imitators of severe preeclampsia that are life-threatening emergencies associated with high maternal mortality (Sibai, 2007).
The two share certain clinical and pathologic features, and for a number of years it was recommended that the two be included within the combined clinical classification of "TTP-HUS".
2 "Thrombotic Thrombocyopenic Purpura-Hemolytic Uremic Syndrome (TTP-HUS): Pathophysiology and Management" Vol.