TTP-HUS

TTP-HUS

Abbreviation for thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. See: thrombotic thrombocytopenic purpura, hemolytic uremic syndrome.

TTP-HUS

The combination of thrombotic thrombocytopenic purpura–TTP and hemolytic-uremic syndrome–HUS, polar expressions of the same disease defined by a pentad of TTP features: Thrombocytopenia, microangiopathic hemolytic anemia, neurologic defects, fever, renal disease Clinical Abrupt onset in children after a viral URI; may be associated with a verotoxin in E coli-induced gastroenteritis; it may occur in pregnancy, at parturition, or during chemotherapy; spontaneously resolving renal failure–RF occurs in 60%–10% progress to chronic RF; RF is more common in E coli O157:H7 infections, which are linked to 16% of cases with HUS Lab Reticulocytosis, ↑ BR, ↑ FDPs without DIC, ↓ haptoglobin Management Most resolve spontaneously, others require high-dose corticosteroids Prognosis with prednisone and plasma exchange, 91% survival
References in periodicals archive ?
coli ESBL induced sepsis could produce a classical pentad of TTP-HUS.
coli ESBL producing a TTP-HUS picture should be considered in patients presenting with classic TTP pentad.
The incidence of acquired TTP is approximately three cases per one million adults per year, based on data from the Oklahoma TTP-HUS Registry.
20 In Oklahoma registry data of 301 patients 13% of all patients, and 33% of patients with idiopathic TTP-HUS, had very severe ADAMTS-13 deficiency (<5% activity).
The Oklahoma thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) registry: a community perspective of patients with clinically diagnosed TTP-HUS.
4) Seventeen TTP-HUS patients with platelet counts < 20,000 underwent 18 central line placements.
TTP-HUS is a hemolytic disorder linked to platelet aggregation and thrombocytopenia with endothelial damage (Obeidat, MacDougall, & Harding, 2002).
According to George (2003), due to the hypercoagulable state that occurs near term and during the postpartum period, and the progressively declining concentration of ADAMTS-13, there is an increased risk for the occurrence of TTP-HUS during late pregnancy.