TTLL6

A gene on chromosome 17q21.32 that encodes a polyglutamylase which preferentially modifies alpha-tubulin. TTLL6 is involved in the side-chain initiation step of polyglutamylation, rather than in the elongation step. TTLL6 is found in a complex with CP41, which is required for its transport between the basal body and the cilium.

References in periodicals archive ?

Kumar et al., "Amyloid-[beta] oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin," The EMBO Journal, vol.

Protective Effects of Wogonin against Alzheimer's Disease by Inhibition of Amyloidogenic Pathway

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