FOXE1

(redirected from TTF2)

FOXE1

An intronless gene on chromosome 9q22 that encodes a member of the forkhead family of transcription factors, specifically a thyroid transcription factor, which plays a crucial role in thyroid morphogenesis.

Molecular pathology
FOXE1 mutations are linked to congenital hypothyroidism and cleft palate with thyroid dysgenesis.
References in periodicals archive ?
Thyroid transcription factors (TTFs) TTF1, paired box gene 8 (PAX8), and TTF2 (FOXE1) are crucial for thyroid organogenesis and differentiation.
However, TTF2 seems to play a role in the development of the negative controller of thyroid-specific gene expression.
There are only few studies in literature investigating TTF2 expression by immunohistochemical analysis in human tumors and normal tissues.
TTF) TTF2 Using the blended e-learning system fits with the way I like to enhance the efficiency of my work.
The most recent phase of the Dragon's Den-style fund, TTF2, offered grants of up to pounds 25,000 to more than 150 local companies.
A total of 50 per cent of companies surveyed for the report indicated that employment levels would have been lower had they not accessed the TTF2 funds, with 20 per cent of these stating that employment levels would be more than 50 per cent lower than at present.
TTF1 and PAX8 are implicated in proliferation and survival of thyroid cell precursors, and TTF2 plays a role in migration and proliferation of thyroid precursors.