TSST-1


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TSST-1

toxic shock syndrome toxin.
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strains PVL Exfoliatin toxin A TSST-1 SCCmec I 21 0 0 11 SCCmec II 1 0 0 0 SCCmec III 1 0 0 0 SCCmec IV ([dagger]) 109 53 11 9 SCCmec V 15 6 0 1 SCCmecNT 4 1 0 1 Total ([section]) 151 60 11 22 agr type Isolates 1 2 3 4 SCCmec I 9 11 1 0 SCCmec II 0 1 0 0 SCCmec III 0 0 1 0 SCCmec IV ([dagger]) 20 24 25 0 SCCmec V 8 ([double dagger]) 3 4 0 SCCmecNT 1 1 2 0 Total ([section]) 38 40 73 0 Isolates Main MLST types SCCmec I 5,149 SCCmec II ND SCCmec III ND SCCmec IV ([dagger]) 158,223,072 808,588,149 SCCmec V 1,305,985,152 SCCmecNT ND Total ([section]) * PVL, Panton-Valentine leukocidin; TSST-1, toxic shock syndrome toxin 1; agr, accessory gene regulator; MLST, multilocus sequence typing; SCCmec, staphylococcal cassette chromosome mec; ND, not determined; NT, nontypeable.
Although TSST-1 production by MRSA strains has been described in Europe (7), this case is the first of TSS due to TSST-l-producing MRSA in Europe.
Staphylococcal exanthematous disease in a newborn due to a virulent methicillin-resistant Staphylococcus aureus strain containing the TSST-1 gene in Europe: an alert for neonatologists.
These stable, secreted toxins of 22 kDa to 30 kDa include staphylococcal enterotoxins serotypes A-E, G, and H; group A streptococcal pyrogenic exotoxins serotypes A-C and F; group A streptococcal superantigen; and staphylococcal TSST-1, which we discuss below.
All PTSAgs share common biological activities, but TSST-1 is the most divergent member of the toxin family, with less than 30% amino acid homology to other family members (52-54).