ACVR1

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ACVR1

A gene on chromosome 2q23-q24 that encodes activin receptor type I, a receptor that forms a complex with other type-I and two type-II transmembrane serine/threonine kinase receptors for activin, a dimeric growth and differentiating factor belonging to the TGF-beta superfamily of structurally related signalling proteins. Type-II receptors phosphorylate and activate type-I receptors, which autophosphorylate, then bind and activate SMAD transcriptional regulators, playing roles in cell differentiation, growth arrest and apoptosis. 

Molecular pathology
ACVR1 mutations are linked to fibrodysplasia ossificans progressive.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Chen remarked at the inaugural ceremony that the government had worked on merging the two research labs into TSRI over the past year, in hopes of providing better assistance for industries and other research institutes in Taiwan to better streamline semiconductor research and development processes, and thereby maintain global competitiveness.
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Precision Medicine Initiative (PMI) Cohort Program through an initial $20 million grant awarded to The Scripps Research Institute (TSRI) by the National Institutes of Health (NIH).
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