CRLF2

(redirected from TSLPR)
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CRLF2

A gene on chromosome Xp22.3 and Yp11.3 that encodes a protein receptor for thymic stromal lymphopoietin (TSLP), which forms a functional complex with TSLP and IL7R and stimulates cell proliferation by activating STAT3 and STAT5, as well as JAK2. It is
implicated in the development of the haematopoietic system.
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References in periodicals archive ?
Therefore, we propose a new idea that abnormal communication may exist between IL-25/IL-33/TSLP and fibrocyte, which forms a functional pathologic pathway (i.e., IL-25/IL-33/TSLP-[IL-17RB + ST2L + TSLPR +] fibrocyte axis) to exert the pathogenesis of airway changes in AADs [Figure 3].
Via TSLP, DCs in the gut may be shifted towards a tolerogenic phenotype (*: TSLPR expression is limited to gut DCs).
The gene array data also did not show any difference in the expression of TSLPR, IL-33R, or ICOSL on aged DCs as compared to young DCs [35].