TSH assay


Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia.

assay

 [as´a]
determination of the purity of a substance or the amount of any particular constituent of a mixture.
biological assay bioassay; determination of the potency of a drug or other substance by comparing the effects it has on animals with those of a reference standard.
CH50 assay a test of total complement activity as the capacity of serum to lyse a standard preparation of sheep red blood cells coated with antisheep erythrocyte antibody. The reciprocal of the dilution of serum that lyses 50 per cent of the erythrocytes is the whole complement titer in CH50 units per milliliter of serum.
enzyme-linked immunosorbent assay (ELISA) any enzyme immunoassay using an enzyme-labeled immunoreactant (antigen or antibody) and an immunoadsorbent (antigen or antibody bound to a solid support). A variety of methods are used for measuring the unknown concentration, such as either competitive binding between the labeled reactant and unlabeled unknown or a sandwich technique in which the unknown antigen binds both the immunoadsorbent and labeled antibody. One of the uses of ELISA is to screen blood for antibody to the human immunodeficiency virus; a positive result indicates probable exposure to the virus and possibly that the virus is in the blood. Since false-positives can occur, a back-up test is used to confirm positive findings.
 ELISA: With antigen capture ELISA, the wells are coated with antibody to the virus. The sample containing virus (1) is added and, after washing several times, enzyme conjugated to an antibody to the virus is added (2). Finally, after a further cycle of washing, the enzyme's substrate (3) is added. A colored product is formed if the viral antigen is present in the sample (4). From Hart and Shears, 1997.
microhemagglutination assay–Treponema pallidum (MHA-TP) a Treponema pallidum hemagglutination assay using microtechniques; used in the detection of syphilis.
radioreceptor assay a radioligand assay in which a radiolabeled hormone is used to measure the concentration of specific cellular receptors for the hormone in tissue specimens, an example being radioassay of estrogen receptors in breast tissue.
thyroid-stimulating hormone assay thyroid-stimulating hormone test.
Treponema pallidum hemagglutination assay (TPHA) a treponemal antigen serologic test for syphilis using tanned sheep red blood cells coated with antigen from the Nichol's strain of Treponema pallidum and treated patient serum; it is similar in sensitivity and specificity to the FTA-ABS test. This test is not useful for individuals who have had syphilis in the past.

TSH assay

thyroid-stimulating hormone test.
References in periodicals archive ?
This suggested the likelihood that the ECi TSH assay was subject to the same interferences as that of the Roche platform.
The results showed that the most discrepant TSH assays (G and C) differed by an average of 39%, which is comparable to other reports (6, 10) and to results from a proficiency testing survey with a fresh-frozen serum material (11).
Recognize assays used to diagnose thyroid disease and the sensitivity for TSH assays.
The first assay introduced in this cartridge was the TSH assay in December of 1996.
But is a third-generation TSH assay needed for most applications?
The Roche TSH assay uses mouse antibody and a human/mouse chimera antibody and is noncompetitive in principle.
The Company currently expects the improved cartridge to be available in the fourth quarter, after which it plans to launch TSH assay (once FDA clearance has been received) and the serum pregnancy assay.
The discrepant thyroid function test results and the absence of clinical symptoms prompted investigations for interference in the TSH assay.
The Company currently expects the improved cartridge to be available in the fourth quarter, at which time it plans to launch the serum pregnancy assay and, upon receipt of FDA clearance, the TSH assay.
The TSH assay is designed to be used with the Company's IOS(TM) immunodiagnostic system to allow testing in physicians' offices and other points of patient care.
However, both mother and child had markedly increased TSH values as measured by the laboratory Dade Behring Dimension TSH assay (mother's TSH, 35.
Rawlins and Roberts (1) cited a single earlier ADVIA Centaur study (3), which they claim agrees with their results; however, the cited study actually evaluated the ADVIA Centaur TSH, a second-generation TSH assay that is different from the TSH-3.