TRPV6


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TRPV6

A gene on chromosome 7q34 that encodes a calcium-permeable channel, which participates in neurotransmission, muscle contraction and exocytosis by providing calcium as an intracellular second messenger; transcellular calcium transport may be regulated by vitamin D, parathyroid hormone or calcitonin. The TRPV6 channel is activated by a low internal calcium levels, and involved in Ca2+ absorption and reabsorption in the kidney and intestine.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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This protein, and its colleague protein TRPV6, ensure that the calcium balance in the body is maintained.
The conceptus derived estrogen induces the expression of many uterine endometrial genes, including AKR1B1, fibroblast growth factor 7 (FGF7), interleukin 1 receptor accessory protein (IL1RAP), lysophosphatidic acid receptor 3 (LPAR3), secreted phosphoprotein 1 (SPP1), signal transducer and activator of transcription 1 (STAT1), and transient receptor potential vanilloid type 6 (TRPV6) [25-27].
Yu, "Lidocaine inhibits the invasion and migration of TRPV6-expressing cancer cells by TRPV6 downregulation," Oncology Letters, vol.
The TRPV subfamily consists of TRPV1-6; TRPV1-4 have thermal sensitivity, and TRPV5 and TRPV6 uptake [Ca.sup.2+] in the kidney and intestine [49].
In exchange, TRP channels such as TRPV6 are upregulated in the plasma membrane of advanced prostate cancer cells which have been proposed to generate in concert with IK [K.sup.+] channels survival and growth factor-independent [Ca.sup.2+] signaling (for review see [42]).
TRPV1, TRPV2 and TRPV6) in cancer growth has recently been reported [34,35].
The protein in question, the TRPV6 calcium channel forming protein, is first provided with an "anchor" to which a gold nanoparticle can bind.
In both young and aged mice, high P diet significantly increased mRNA expression of TRPV6, CaBP9k, and PMCAlb (Figure 2) compared to the control diet.
Frey, "Gain-of-function haplotype in the epithelial calcium channel TRPV6 is a risk factor for renal calcium stone formation," Human Molecular Genetics, vol.
Epithelial cancers such as breast, ovarian and prostate contain a calcium "channel" known as TRPV6 (transient receptor potential vanilloid family number 6) that, for reasons as-yet unknown, brings an abnormal amount of calcium into cancer cells.
It was shown that TRPV6, a calcium channel protein related to TRPV1, might mediate capsaicin-induced gastric cancer cell death.