This protein, and its colleague protein TRPV6
, ensure that the calcium balance in the body is maintained.
The conceptus derived estrogen induces the expression of many uterine endometrial genes, including AKR1B1, fibroblast growth factor 7 (FGF7), interleukin 1 receptor accessory protein (IL1RAP), lysophosphatidic acid receptor 3 (LPAR3), secreted phosphoprotein 1 (SPP1), signal transducer and activator of transcription 1 (STAT1), and transient receptor potential vanilloid type 6 (TRPV6
Yu, "Lidocaine inhibits the invasion and migration of TRPV6-expressing cancer cells by TRPV6
downregulation," Oncology Letters, vol.
The TRPV subfamily consists of TRPV1-6; TRPV1-4 have thermal sensitivity, and TRPV5 and TRPV6
uptake [Ca.sup.2+] in the kidney and intestine .
In exchange, TRP channels such as TRPV6
are upregulated in the plasma membrane of advanced prostate cancer cells which have been proposed to generate in concert with IK [K.sup.+] channels survival and growth factor-independent [Ca.sup.2+] signaling (for review see ).
TRPV1, TRPV2 and TRPV6
) in cancer growth has recently been reported [34,35].
The protein in question, the TRPV6
calcium channel forming protein, is first provided with an "anchor" to which a gold nanoparticle can bind.
In both young and aged mice, high P diet significantly increased mRNA expression of TRPV6
, CaBP9k, and PMCAlb (Figure 2) compared to the control diet.
Frey, "Gain-of-function haplotype in the epithelial calcium channel TRPV6
is a risk factor for renal calcium stone formation," Human Molecular Genetics, vol.
Epithelial cancers such as breast, ovarian and prostate contain a calcium "channel" known as TRPV6
(transient receptor potential vanilloid family number 6) that, for reasons as-yet unknown, brings an abnormal amount of calcium into cancer cells.
It was shown that TRPV6
, a calcium channel protein related to TRPV1, might mediate capsaicin-induced gastric cancer cell death.