TRPV6


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TRPV6

A gene on chromosome 7q34 that encodes a calcium-permeable channel, which participates in neurotransmission, muscle contraction and exocytosis by providing calcium as an intracellular second messenger; transcellular calcium transport may be regulated by vitamin D, parathyroid hormone or calcitonin. The TRPV6 channel is activated by a low internal calcium levels, and involved in Ca2+ absorption and reabsorption in the kidney and intestine.
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Epithelial cancers such as breast, ovarian and prostate contain a calcium "channel" known as TRPV6 (transient receptor potential vanilloid family number 6) that, for reasons as-yet unknown, brings an abnormal amount of calcium into cancer cells.
This lack of toxicity is a holy grail in cancer treatment--as, it turns out, was the TRPV6 channel.
In pigs, we have shown that uterine endometrial TRPV6 and S100G are expressed in the uterine endometrium in a pregnancy status- and stagespecific manner during the estrous cycle and pregnancy in pigs (Choi et al.
In our previous study, it has been shown that endometrial TRPV6 expression is increased by estrogen during the implantation period (Choi et al.
Previously, we have shown that TRPV6 is expressed in the uterine endometrium during early pregnancy and up-regulated by [E.
Results of the study showed that porcine conceptus during early pregnancy expressed S100G, suggesting that calcium absorption and transport system may be important for early embryo development in pigs, since TRPV6 is also expressed in conceptus trophectoderm during early pregnancy.
Dynamic expression of calcium-regulatory molecules, TRPV6 and S100G, in the uterine endometrium during pregnancy in pigs.
Uterine TRPV6 expression during the estrous cycle and pregnancy in a mouse model.
Calcium uptake requires epithelial calcium channel TRPV6 and to a lesser extent epithelial calcium channel TRPV5 calbindin D transport calcium across the cell and plasma membrane Ca+channels, prealbumin and NA+, Ca++ exchanger mediate the final delivery of Calcium to the blood stream (12).
The expression of TRPV5 and TRPV6 channels is reduced in the VDR null mice.