TRPV5


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TRPV5

A gene on chromosome 7q35 that encodes a calcium-selective cation channel which has 6 transmembrane-spanning domains, forms homo- or heterotetramers and is activated by a low internal calcium levels. The TRPV5 channel is activated by a low internal calcium levels, and is involved in Ca2+ absorption and reabsorption in the kidney and intestine.
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Mark researched the protein structure of TRPV5, a protein in the kidneys.
PTH directly increases calcium reabsorption in the distal nephron of the kidney through TRPV5 (transient receptor potential vanilloid 5) and also increases the expression of various calcium transport proteins.
It has been reported that klotho may increase the abundance on plasma membranes of transient receptor potential vanilloid receptor-related channels (TRPV5); it may interact with the [Na.sup.+]/[K.sup.+] ATPase and insulin receptors and strengthen the affinity between fibroblast growth factors 19, 21, and 23 (FGF19, FGF21, and FGF23) and their receptors [15-17].
The TRPV subfamily consists of TRPV1-6; TRPV1-4 have thermal sensitivity, and TRPV5 and TRPV6 uptake [Ca.sup.2+] in the kidney and intestine [49].
Ye et al., "Estrogen inhibits RANKLinduced osteoclastic differentiation by increasing the expression of TRPV5 channel," Journal ofCellularBiochemistry, vol.
Hypervitaminosis D mediates compensatory [Ca.sup.2+] hyperabsorption in TRPV5 Knockout mice.
Calcium uptake requires epithelial calcium channel TRPV6 and to a lesser extent epithelial calcium channel TRPV5 calbindin D transport calcium across the cell and plasma membrane Ca+channels, prealbumin and NA+, Ca++ exchanger mediate the final delivery of Calcium to the blood stream (12).
The first step of transcellular calcium transport is the influx of extracellular calcium ion into the epithelial cells by transient receptor potential vanilloid type 5 (TRPV5) and 6 (TRPV6).