TRPV5


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TRPV5

A gene on chromosome 7q35 that encodes a calcium-selective cation channel which has 6 transmembrane-spanning domains, forms homo- or heterotetramers and is activated by a low internal calcium levels. The TRPV5 channel is activated by a low internal calcium levels, and is involved in Ca2+ absorption and reabsorption in the kidney and intestine.
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PTH directly increases calcium reabsorption in the distal nephron of the kidney through TRPV5 (transient receptor potential vanilloid 5) and also increases the expression of various calcium transport proteins.
Calcium uptake requires epithelial calcium channel TRPV6 and to a lesser extent epithelial calcium channel TRPV5 calbindin D transport calcium across the cell and plasma membrane Ca+channels, prealbumin and NA+, Ca++ exchanger mediate the final delivery of Calcium to the blood stream (12).
The expression of TRPV5 and TRPV6 channels is reduced in the VDR null mice.