TRPV4


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TRPV4

A gene on chromosome 12q24.1 that encodes a calcium-permeable, non-selective cation channel thought to be involved in regulating systemic osmotic pressure. It is activated by exposure to hypotonicity within the physiological range, as well as by low pH, citrate and phorbol esters. Channel activity may be a calmodulin-dependent mechanism with a negative feedback control. TRPV4 promotes cell–cell junction formation in the skin and plays an important role in forming and maintaining intercellular barriers; it also regulates intracellular Ca2+ and hypotonic stimulation in synoviocytes and regulates production of IL-8.

Molecular pathology
TRPV4 mutations cause spondylometaphyseal and metatropic dysplasia, and hereditary motor and sensory neuropathy type IIC.
References in periodicals archive ?
Using MMP-1 reporter assays, we found that TRPV4-specific siRNA decreased MMP-1 transcriptional activation, thus implying that TRPV4 is critical for DEP/ OE-evoked [Ca.sup.2+] influx, which then activates MMP-1 [see Supplemental Material, Figure 5D (doi:10.1289/ehp.1002807)1.
Pyle et al., "Phenotypic variability of TRPV4 related neuropathies, " Neuromuscular Disorders, vol.
When activated by phytochemicals, TRPs stimulate either a sensation of warmth or a sensation of cooling: TRPV1, TRPV3, and TRPV4 channels are involved in heat sensation, such as that induced by chili peppers (capsaicin) or ginger, while TRPM8 channels are associated with cold sensation, such as that induced by mint (Table 4) [1].
Ion channel upregulation including TRPM7, TRPV4, P2X7, and ASIC1a has been reported during the activation of HSCs, which is a major event during fibrogenesis.
Sokabe said: "This is the first report to show that TRPV4 is a primal stretch-detector in urothelial cells.
TRPV4, expressed in sensory nerve endings in the atrial endocardium
The researchers engineered a noninvasive magnet-based technology to create fever-like conditions in two specific temperature-sensitive ion channels called TRPV1 and TRPV4 in the neural crest cells involved in developing the heart and face.
Drosophila TRPN is directly sensitive to light touch, while TRPV4 in mammalian endothelial and renal cells is activated by fluid shear stress via a phospholipase A-dependent pathway.
(47, 63) TRPC1 and TRPC4, the closest relatives of TRPC5, as well as the thermosensor channels TRPV1, TRPV3 and TRPV4, carry Cys residues corresponding to Cys553 and Cys558 in the TRPC5 protein.
Transient receptor potential vanilloid 4 (TRPV4) and transient receptor potential ankyrin 1 (TRPA1) have already been main focuses for comparatively mature studies currently.
The researchers believe that the protein TRPV4, which is known to be a factor in heat sensitivity, could be a mediator in the pain response for these rats.