TRPV4


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TRPV4

A gene on chromosome 12q24.1 that encodes a calcium-permeable, non-selective cation channel thought to be involved in regulating systemic osmotic pressure. It is activated by exposure to hypotonicity within the physiological range, as well as by low pH, citrate and phorbol esters. Channel activity may be a calmodulin-dependent mechanism with a negative feedback control. TRPV4 promotes cell–cell junction formation in the skin and plays an important role in forming and maintaining intercellular barriers; it also regulates intracellular Ca2+ and hypotonic stimulation in synoviocytes and regulates production of IL-8.

Molecular pathology
TRPV4 mutations cause spondylometaphyseal and metatropic dysplasia, and hereditary motor and sensory neuropathy type IIC.
References in periodicals archive ?
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.
Low intravascular pressure activates endothelial cell TRPV4 channels, local [Ca.
2012) The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia.
17] Since TRPA1 and TRPV4 are the two key participants in mechanical hyperalgesia, together with their high co-expression and synergy effect with TRPV1, it is concluded that TRPA1 and TRPV4 mediated mechanical hyperalgesia is more critical in KOA pain.
These recent findings on Aldh1a1, Them1 and TRPV4 provide a deeper understanding of the pathways and mechanisms that relate to brown fat," said Louis Tartaglia, Ph.
Ion channel upregulation including TRPM7, TRPV4, P2X7, and ASIC1a has been reported during the activation of HSCs, which is a major event during fibrogenesis.
A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery.
The novel concept of air pollution--responsive ciliary signal transduction from PAR-2 to TRPV4 in human respiratory epithelia will accelerate rationally targeted therapies, possibly via the inhalatory route.
Small Molecule Inhibition of Key Ion Channel Could Represent a New Therapeutic Approach to Metabolic Disease; Ember Holds Exclusive Licensing Option on TRPV4 Intellectual Property
Hyperglycemia and diabetes downregulate the functional expression of TRPV4 channels in retinal microvascular endothelium," PLoS ONE, vol.
Prof Ravi Savarirayan of Victorian Clinical Genetics Services said that the researchers who studied the family found that all family members who were affected by osteoarthritis had the faulty gene TRPV4.
The researchers said that those phenomena were almost completely attributed to TRPV4 activation, since such responses were eliminated by a TRPV4 inhibitor and reduced in TRPV4-deficient urothelial cells.