TRPV2


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TRPV2

A gene on chromosome 17p11.2 that encodes a calcium-permeable, non-selective cation channel activated by high temperatures above 52ºC in sensory ganglia, and activated by other stimuli in other tissues. It appears to be regulated in part by IGF-I, PDGF and neuropeptide head activator.
References in periodicals archive ?
(20.) Iwata, Y., Katayama, Y., Okuno, Y., Wakabayashi, S., Novel inhibitor candidates of TRPV2 prevent damage of dystrophic myocytes and ameliorate against dilated cardiomyopathy in a hamster model.
2-aminoethoxydiphenyl borate as a common activator of TRPV 1, TRPV2, and TRPV3 channels.
What is more, BTX-A exerts an antinociceptive function, directly modulating central sensitization by inhibiting excessive expression of TRPA1, TRPV1, and TRPV2 in the spinal trigeminal nucleus [21, 22].
Cortright, "Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury," Biochemical and Biophysical Research Communications, vol.
Within the TRP family, there are four different molecules (TRPV1, TRPV2, TRPV3, and TRPV4) that respond to different degrees of temperature increase, ranging from the perception of heat all the way up to harmful levels [24-26].
Wakabayashi, "Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models," Human Molecular Genetics, vol.
Wu et al., "Effect of mild moxibustion with different temperature for visceral sensitive and TRPV1 protein and TRPV2 protein on ST25 of IBS model rats," China Association of Acupuncture and Moxibustion, 2013.
(9) Interestingly, CBD exhibits little affinity for cannabinoid receptors, with research demonstrating it is an agonist at 5HT1A, TRPV1 and TRPV2 receptors whilst also enhancing [alpha]1 and [alpha]3 glycine receptor activity.
TRPV1, TRPV2 and TRPV6) in cancer growth has recently been reported [34,35].
(2008) TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons.