TRPV1


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TRPV1

A gene on chromosome 17p13.2 that encodes a protein which is a receptor for capsaicin and the structurally related vanilloids, and is a non-selective cation channel structurally related to the TRP family of ion channels. The receptor is also activated by high temperatures, suggesting that it functions as a transducer of noxious chemical and painful thermal stimuli in vivo.
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Furthermore, capsaicin could activate the vanilloid receptor subtype 1 (TRPV1), and change the cytokine framework to protect periodontal tissues (Zhou et al., 2014).
The research results suggested that thermal dependent moxibustion stimulating ST36 activates TRPV1 in peripheral sensory nerves, reduced PVN neuronal activity through the opioid system, and decreased sympathoexcitatory cardiovascular reflex responses.
Involvement of TRPV1 channels in the activity of the cannabinoid WIN 55,212-2 in an acute rat model of temporal lobe epilepsy.
Suppression of network activity in dorsal horn by gabapentin permeation of TRPV1 channels: implications for drug access to cytoplasmic targets.
The Role of Transient Receptor Potential Vanilloid 1 (Trpv1) Receptors in Dextran Sulfate-Induced Colitis in Mice.
(11) Thus, the current theory to explain CHS is that chronic cannabinoid exposure inactivates the TRPV1 receptors.
Abundant expression and functional participation of TRPV1 at Zusanli acupoint (ST36) in mice: mechanosensitive TRPV1 as an "acupuncture-responding channel".
After differentiation, they acquired a sensory neuron phenotype exhibiting a bipolar neuronal morphology and expressed neuronal markers (Brn3a, p75NTR and peripherin, TRPV1 channel).
The OSCC cell line has been observed with increased expression of Transient Receptor Potencial Vanilloid (TRPV1), which is activated by HPETE (a product of ALOX12B-mediated reactions).
Of all these channels, TRPV1 has long been a focus for concern.
Transient receptor potential V1 (TRPV1) was found to be expressed in primary sensory neurons and plays an important role in mediating heat pain and heat hyperalgesia after injury [47].