TRPV1


Also found in: Acronyms, Wikipedia.

TRPV1

A gene on chromosome 17p13.2 that encodes a protein which is a receptor for capsaicin and the structurally related vanilloids, and is a non-selective cation channel structurally related to the TRP family of ion channels. The receptor is also activated by high temperatures, suggesting that it functions as a transducer of noxious chemical and painful thermal stimuli in vivo.
Mentioned in ?
References in periodicals archive ?
Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites.
In the periphery, FAAH inhibition mediates anti-inflammatory effects by down regulating cytokine production and the desensitization of TRPV1, resulting in analgesia (15).
Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain.
In addition, administering HEPm or ISO markedly reduced nociceptive behavior induced by the peripheral and central injection of TRPV1 and TRPA1 channels activators.
El TRPV1 es un canal cationico no selectivo expresado en neuronas sensoriales primarias nociseptivas de fibras nerviosas tipo A delta y tipo C, se activa por estimulos de calor, pH extracelular bajo, gran variedad de lipidos incluyendo anandamida, dopamina y algunos ecosanoides (5).
Onabotulinumtoxin-A intradetrusorial injections modulate bladder expression of NGF, TrkA, p75 and TRPV1 in patients with detrusor overactivity," Pharmacological Research, vol.
Changes in TRPV1 expression occur during the development of human urothelial cancer [36].
In this case, NEO6860, which acts at the TRPV1 ion channel, interferes with one of the mechanisms that generate the painful symptoms of diseases such as osteoarthritis.
These findings were reported in an article entitled "Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates" in a December 2014 issue of Bioorganic & Medicinal Chemistry Letters.
In individuals with healthy skin, TRPV1 activation produces brief periods of flushing and burning pain.
There is a receptor on the nerves called TRPV1 (transient receptor potential cation channel, subfamily V [vanilloid], member 1), whose previous name was the capsaicin receptor.