TRPM8


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TRPM8

A gene on chromosome 2q37.1 that encodes a receptor-activated, nonselective cation channel involved in detecting of sensations (e.g., low temperatures, when it is activated by temperature < 25ºC). TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH.
References in periodicals archive ?
39) Menthol has been shown to help regulate cold and pain sensation through the TRPM8 receptor.
15] and coverage >40% to mammalian TRPM2 (Lp1), TRPM8 (Lp2), TRPP1 (Lp3), and TRPP2 (Lp4 and Lp5), as well as Xenopus laevis TRPM8 (Lp2).
The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity.
TRPM8 subtype exhibits activation at a room temperature <27[degrees]C that is when there is a slight cold.
The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain.
Menthol is a natural compound of plant origin known to produce cool sensation via the activation of the TRPM8 channel.
The melastatin subfamily (TRPM) has been subdivided into three subgroups on the basis of sequence homology (TRPM1/TRPM3, TRPM4/ TRPM5, and TRPM6/7) with TRPM8 and TRPM2 being distinct proteins [3].
Brauchi S, Orio P, Latorre R (2004) Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8.
The TRP channels involved in pain are TRPV1-V4, TRPA1, and TRPM8 [120].
In prior work, McKemy discovered a link between the experience of cold and a protein known as TRPM8 (pronounced trip-em-ate), which a sensor of cold temperatures in neurons in the skin, as well as a receptor for menthol, the cooling component of mint.
In prior work, David McKemy, associate professor of neurobiology in the USC Dornsife College of Letters, Arts and Sciences, discovered a link between the experience of cold and a protein known as TRPM8 (pronounced trip-em-ate), which a sensor of cold temperatures in neurons in the skin, as well as a receptor for menthol, the cooling component of mint.