TRPM7


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TRPM7

A gene on chromosome 15q21 that encodes an essential ion channel and serine/threonine-protein kinase, which is required for magnesium homeostasis and in the regulation of anoxic neuronal cell death.
References in periodicals archive ?
Touyz, "Dysregulation of vascular TRPM7 and annexin-1 is associated with endothelial dysfunction in inherited hypomagnesemia," Hypertension, vol.
Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels.
Stimulates TRP-related responses in leach (100 [micro]mol [1.sup.-1]) and mealworm (0.1 [micro]mol [1.sup.-1]) (Caterina et al., 1997; Olszewska and Tegowska, 2011; Cao et al., 2013; Summers et al., 2014; Su et al., 2017) RN1747 Activates mammalian TRPV4 (1-4 [micro]mol [1.sup.-1]) (Vincent et al., 2009; Vriens et al., 2009; Vincent and Duncton, 2011) Antagonists Carvacrol Inhibits mammalian TRPM7 and Drosophila TRPL (50-500 [micro]mol [1.sup.-1]).
(93) Other redox-sensitive TRPs (TRPC1, TRPC4, TRPM2 and TRPM7) (47) that by themselves do not respond to reactive disulphides including 5-nitro-2PDS (10 [micro]M) failed to respond to hyperoxia.
Other redox-sensitive TRPs except for TRPM7 failed to respond to hypoxia.
In addition to TRPA1, we found that TRPM7, which was originally known for activation by anoxia, (40) is capable of responding to milder hypoxic conditions prepared by bubbling [N.sub.2] gas into the assay solution.
In this study, we compared the TRPM7 protein expression between control prostate cells and PCa cells.
Lentivirus plasmids were obtained from Addgene (Cambridge, MA) in pLKO.1 cloning vector and contained either nonspecific control shRNA (sh-Control) or shRNA specific for human TRPM7 (GeneBank: AY032950).
We determined TRPM7 protein expression in RWPE-1, PC-3, and DU145 cells.
Paulsen et al., "Defective skeletogenesis with kidney stone formation in dwarf zebrafish mutant for trpm7," Current Biology, vol.
Hill, "Differential expression of TRPM7 in rat hepatoma and embryonic and adult hepatocytes," Canadian Journal of Physiology and Pharmacology, vol.
Shi, "Electro-acupuncture regulates TRPM7 expression through the trkA/PI3K pathway after cerebral ischemia-reperfusion in rats," Life Sciences, vol.