TRPM7


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TRPM7

A gene on chromosome 15q21 that encodes an essential ion channel and serine/threonine-protein kinase, which is required for magnesium homeostasis and in the regulation of anoxic neuronal cell death.
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2003) A key role for TRPM7 channels in anoxic neuronal death.
TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in [O.sub.2] sensing
TRPM7 Knockdown Regulates the Functions of Prostate Cancer Cells.
Consistently, TRPM7 knockdown inhibited PC-3 cell proliferation, migration, and invasion.
TRPM7 downexpression decreases the phosphorylation of p-Akt in ovarian cancer cells and lung fibroblasts and also decreases the phosphorylation of p-ERK1/2 in breast cancer cells [8, 33, 34].
2+] ratio promotes proliferation of prostate cancer cells by activating TRPM7 channels," Journal of Biological Chemistry, vol.
Singh, "Cholesterol-induced activation of TRPM7 regulates cell proliferation, migration, and viability of human prostate cells," Biochimica et Biophysica Acta (BBA)--Molecular Cell Research, vol.
Li, "Inhibition of TRPM7 channels prevents proliferation and differentiation of human lung fibroblasts," Inflammation Research, vol.
Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways
Ion channel upregulation including TRPM7, TRPV4, P2X7, and ASIC1a has been reported during the activation of HSCs, which is a major event during fibrogenesis.
2 Acute liver injury TRPM2 Acetaminophen-induced liver damage TRPM7 Liver fibrosis TRPV4 Liver fibrosis P2Y Liver fibrosis P2X7 Liver fibrosis NASH CLIC1 Hepatocarcinoma ASIC1a Liver fibrosis VSOR Hepatoma VDAC Acute ethanol intoxication Ion channel Model [K.
Ion Channels and Oxidative Stress as a Potential Link for the Diagnosis or Treatment of Liver Diseases

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