TRPM5


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TRPM5

A gene on chromosome 11p15.5 which encodes a voltage-modulated, Ca2+-activated, monovalent (VCAM) cation channel, which mediates transient membrane depolarisation and plays a central role in taste transduction. TRPM5 may be involved in sensing bitter, sweet and umami tastes, and in sensing semiochemicals.
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Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells.
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.
The melastatin subfamily (TRPM) has been subdivided into three subgroups on the basis of sequence homology (TRPM1/TRPM3, TRPM4/ TRPM5, and TRPM6/7) with TRPM8 and TRPM2 being distinct proteins [3].
According to the study, the reaction of TRPM5 in our taste buds is much more intense when the temperature of food or fluid is increased, sending a stronger electrical signal to the brain and resulting in an enhanced taste.
At 15 degrees Celsius the TRPM5 channel scarcely opens, whereas at 37 degrees Celsius its sensitivity is more than 100 times higher.
TRPM5, a taste-signaling transient receptor potential ion-channel, in a ubiquitous signaling component in chemosensory cells.