TRPM5


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TRPM5

A gene on chromosome 11p15.5 which encodes a voltage-modulated, Ca2+-activated, monovalent (VCAM) cation channel, which mediates transient membrane depolarisation and plays a central role in taste transduction. TRPM5 may be involved in sensing bitter, sweet and umami tastes, and in sensing semiochemicals.
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Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells.
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.
The melastatin subfamily (TRPM) has been subdivided into three subgroups on the basis of sequence homology (TRPM1/TRPM3, TRPM4/ TRPM5, and TRPM6/7) with TRPM8 and TRPM2 being distinct proteins [3].
According to the study, the reaction of TRPM5 in our taste buds is much more intense when the temperature of food or fluid is increased, sending a stronger electrical signal to the brain and resulting in an enhanced taste.
At 15 degrees Celsius the TRPM5 channel scarcely opens, whereas at 37 degrees Celsius its sensitivity is more than 100 times higher.
TRPM5, a taste-signaling transient receptor potential ion-channel, in a ubiquitous signaling component in chemosensory cells.
As we keep in mind the future growth of the Company, we have worked diligently to retain key staff to maintain the core competencies necessary to support our taste-related research programs, and to continue leveraging our research on modulators of the TRPM5 ion channel to explore new opportunities for the discovery of diabetes or obesity therapeutics.
This study is the first to examine the precise mechanism underlying the unpalatability of pharmaceutical drugs and has shown that many of these drugs conduct their bad taste response through a specific taste-cell protein known as the TRPM5 ion channel.
Patent and Trademark Office, covering the use of assay technology used to identify modulators of the TRPM5 ion channel;
Patent and Trademark Office, covering the use of assay technology used for the purpose of identifying potential activators of the TRPM5 ion channel (formerly known as the TRP8 ion channel).
Patent and Trademark Office, covering the use of assay technology used for the purpose of identifying modulators of the TRPM5 ion channel (formerly known as the TRP8 ion channel).
During the quarter, Senomyx strengthened its position as a leader in the science of human taste by entering into an exclusive license agreement with The Queens Medical Center, Honolulu, Hawaii, regarding patent rights relating to the use of the TRPM5 ion channel to modulate sweet, bitter, and savory tastes.