TRPM4


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TRPM4

A gene on chromosome 19q13.33 that encodes a calcium-activated nonselective (CAN) cation channel, which mediates membrane depolarisation of cardiac myocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells and others. TRPM4 participates in T-cell activation by modulating Ca2+ after T-cell activation, which is required for NFAT-dependent IL2 production; it controls insulin secretion, and it may be involved in cardiac pacing or trigger arrhythmias in the face of Ca2+ overload. It also affects T-helper (Th1 and Th2) cell motility and cytokine production by differential regulation of calcium signalling and NFATC1 localisation. It enhances cell proliferation by upregulating the beta-catenin-signalling pathway.
References in periodicals archive ?
Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries.
Genetic sequencing showed that no known mutation of cardiomyopathy was detected, but he had three mutant heterozygotes in TGFBR2 , SMAD9 , TRPM4 gene which did not find a link with this disease.
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.