TRPM2


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TRPM2

A gene on chromosome 21q22.3 that encodes a nonselective,  voltage-independent cation channel, which mediates sodium and calcium ion influx in response to oxidative stress. TRPM2 is activated by ADP-ribose, NAD+, reactive oxygen species and arachidonic acid; it confers susceptibility to cell death in response to oxidative stress, and is inactivated by intracellular ATP.
References in periodicals archive ?
Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation.
Identification of novel sense and antisense transcription at the TRPM2 locus in cancer.
7] Human genes: B2M, beta-2-microglobulin; CSMD2, CUB and Sushi multiple domains 2; C14orf102, chromosome 14 open reading frame 102; CNTNAP5, contactin associated protein-like 5; NRDE2, NRDE-2, necessary for RNA interference, domain containing; ADAM6, ADAM metallopeptidase domain 6, pseudogene; TRPM2, transient receptor potential cation channel, subfamily M, member 2.