TRPM2


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TRPM2

A gene on chromosome 21q22.3 that encodes a nonselective,  voltage-independent cation channel, which mediates sodium and calcium ion influx in response to oxidative stress. TRPM2 is activated by ADP-ribose, NAD+, reactive oxygen species and arachidonic acid; it confers susceptibility to cell death in response to oxidative stress, and is inactivated by intracellular ATP.
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References in periodicals archive ?
(93) Other redox-sensitive TRPs (TRPC1, TRPC4, TRPM2 and TRPM7) (47) that by themselves do not respond to reactive disulphides including 5-nitro-2PDS (10 [micro]M) failed to respond to hyperoxia.
(2005) TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors.
This study demonstrated that TRPM2 can negatively regulate the LPS-ATP-induced caspase-1-dependent pyroptosis in bone marrow-derived macrophage and the possible mechanism might be related to the modulation of ROS production.
As we know, TRPM2 has a protective role in the regulation of inflammatory disorders/immune disease.
Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation.
Identification of novel sense and antisense transcription at the TRPM2 locus in cancer.
Yao, "Role of TRPM2 in [H.sub.2][O.sub.2]-induced cell apoptosis in endothelial cells," PLoS One, vol.
Penner, "Cyclic ADPribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels," Molecular Cell, vol.
Mittal et al., "Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis," Circulation Research, vol.
The melastatin subfamily (TRPM) has been subdivided into three subgroups on the basis of sequence homology (TRPM1/TRPM3, TRPM4/ TRPM5, and TRPM6/7) with TRPM8 and TRPM2 being distinct proteins [3].
[Ca.sup.2+]-Signaling by TRPM2, Bcl-2, and Mitochondria.
Naziroglu, "Melatonin modulates apoptosis and TRPM2 channels in transfected cells activated by oxidative stress," Physiology & Behavior, vol.