TRPM2


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TRPM2

A gene on chromosome 21q22.3 that encodes a nonselective,  voltage-independent cation channel, which mediates sodium and calcium ion influx in response to oxidative stress. TRPM2 is activated by ADP-ribose, NAD+, reactive oxygen species and arachidonic acid; it confers susceptibility to cell death in response to oxidative stress, and is inactivated by intracellular ATP.
References in periodicals archive ?
2006) TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion.
2011) Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice.
2013) Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury.
2013) TRPM2 links oxidative stress to NLRP3 inflammasome activation.
2013) Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction.
2016) The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia.
7] Human genes: B2M, beta-2-microglobulin; CSMD2, CUB and Sushi multiple domains 2; C14orf102, chromosome 14 open reading frame 102; CNTNAP5, contactin associated protein-like 5; NRDE2, NRDE-2, necessary for RNA interference, domain containing; ADAM6, ADAM metallopeptidase domain 6, pseudogene; TRPM2, transient receptor potential cation channel, subfamily M, member 2.
To activate TRPM2 channels, ADP-ribose (1 [micro]M, Sigma, Taufkirchen, Germany) was added to the pipette solution.
Via the cBIOportal Web resource [33, 34], 178 hematopoietic and lymphoid tissue cancer cell lines of the Novartis and Broad Institute Cancer Cell Line Encyclopedia [35] were queried for TRPM2 and Bcl-2 mRNA abundance.
25 h), irradiated (5 Gy), and postincubated (4 h) in the presence of the TRPM2 channel inhibitor ACA (20 [micro]M).
Next, the functional expression of TRPM2 channels and its dependence on Bcl-2 was determined in Jurkat cells.
To activate TRPM2 in Jurkat cells, whole-cell currents were recorded with the TRPM2 agonist ADP-ribose in the pipette and compared in unpaired experiments with those recorded under control conditions.