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TRPM1A gene on chromosome 15q13.3 that encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels, which is expressed in melanocytes and may play a role in melanin synthesis.
TRPM1 mutations are associated with autosomal recessive complete congenital stationary night blindness-1C. Melastatin levels are inversely correlated with melanoma aggressiveness and thus useful prognostic markers for melanoma metastasis.
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