TRPM1


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TRPM1

A gene on chromosome 15q13.3 that encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels, which is expressed in melanocytes and may play a role in melanin synthesis.
 
Molecular pathology
TRPM1 mutations are associated with autosomal recessive complete congenital stationary night blindness-1C. Melastatin levels are inversely correlated with melanoma aggressiveness and thus useful prognostic markers for melanoma metastasis.
References in periodicals archive ?
In molecular terms, the study strongly suggested that nyctalopin coordinates the assembly and precise delivery to the synapse of the macromolecular complex consisting of mGluR6, a neurotransmitter receptor protein, which directly communicates with rod photoreceptors and TRPM1, a protein channel that generates the response, making vision possible.
18) The importance of MLSN-1 in melanoma progression is further evidenced by the fact that microphthalmia-associated transcription factor, an essential melanocyte transcription factor and a specific melanocytic marker, regulates the expression of MLSN-1, also known as TRPM1, in a series of melanoma cells lines.