RANBP2

(redirected from TRP2)
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RANBP2

A gene on chromosome 2q12.3 that encodes a very large RAN-binding protein that immunolocalises to the nuclear pore complex. It is a scaffold and mosaic cyclophilin-related nucleoporin involved in the Ran-GTPase cycle; it interacts directly with the E2 enzyme UBC9 and enhances the transfer of SUMO1 (sumoylation) to its target SP100. RANBP2 is partially duplicated in a gene cluster that lies in the chromosome 2 recombination hot spot.
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As ImmuneRegen and Scancell move towards the clinic independently, we feel this is the ideal time to collaborate on this project, with the goal of evaluating the combination of Scancell's dendritic cell targeting technology as applied to these melanoma antigens** and ImmuneRegen's Homspera[R], which has shown dendritic cell immunostimulatory activity via dendritic cell responses to TRP2 directed against melanoma tumors.