RANBP2

(redirected from TRP2)
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RANBP2

A gene on chromosome 2q12.3 that encodes a very large RAN-binding protein that immunolocalises to the nuclear pore complex. It is a scaffold and mosaic cyclophilin-related nucleoporin involved in the Ran-GTPase cycle; it interacts directly with the E2 enzyme UBC9 and enhances the transfer of SUMO1 (sumoylation) to its target SP100. RANBP2 is partially duplicated in a gene cluster that lies in the chromosome 2 recombination hot spot.
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We further tested the protein expression of TRP1, TRP2, tyrosinase, and [beta]-catenin in different experimental groups by western blots.
Abbreviations Ad: Adenovirus DP: Dermal papillae HF: Hair follicle IRS: Inner root sheath ORS: Outer root sheath sFRP4: Secreted frizzled-related protein 4 sHG: Second hair germ McSC: Melanocyte stem cell TRP1: Tyrosinase-related protein 1 TRP2: Tyrosinase-related protein 2 TYR: Tyrosinase Wnt: Wingless-type MMTV integration site family X-gal: 5-Bromo-4-chloro-3-indolyl-[beta]-D-galactoside.
(a) Double staining shows colocalization of PCNA and TRP2 (white arrow, PCNA), and statistical chart reveals PCNA-positive proliferative cells in the hair follicles after sFRP4 or PBS treatment.
TRP2 was approximately 500 meters away from the eastern room.
The enemy shifted to TRP4 and TRP2. This is when we noticed the scouting element.
Essentially, the same conclusion has been reached by Jianzhi Zhang and David Webb of the University of Michigan in Ann Arbor, who report a similar study of the same VNO gene, which they call TRP2, in the July 8 PNAS.
Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science 295: 1493-15130.