TRMT1

TRMT1

A gene on chromosome 19p13.2 that encodes a methyltransferase which dimethylates a guanine residue of most tRNAs using S-adenosyl-L-methionine as methyl donor.
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In the pathogenesis of NAFLD&NASH in Figure 5, we identified eight genes having expression difference between normal liver cells and NAFLD&NASH, i.e., HIST2H2BE (p value [less than or equal to] 1.06 x [10.sup.-1]), RFC5 (p value [less than or equal to] 1.5 x [10.sup.-2]), HSPB1 (p value [less than or equal to] 6.6 x [10.sup.-2]), ZNF480 (p value [less than or equal to] 1.0 x [10.sup.-2]), TUBA1C (p value [less than or equal to] 3.48 x[ 10.sup.-]1), RPL30 (p value [less than or equal to] 1 x [10.sup.-3]), FRAT2 (p value [less than or equal to] 1.08 x [10.sup.-1]), and TRMT1 (p value [less than or equal to] 5.33 x [10.sup.-1]).
In NAFLD&NASH, we observed that oxidative stress could activate epidermal growth factor receptor (EGFR) to facilitate (i) UBC to repress HSF1 in the WNT and MAPK signaling pathways; (ii) APP to activate ETS1 in the MAPK signaling pathway to induce DNA repair function through the mediation of RFC5, to activate metabolism through the mediation of TRMT1, and to inhibit apoptosis through the mediation of ZNF480; and (iii) SHC1 to repress STAT5A in the MAPK signaling pathway.
In addition, we also found nine genes that play a central role in the upper progression path of Figure 1(a), i.e., two DNA repair-related genes (histone cluster 2 (H2be; HIST2H2BE) and replication factor C5 (RFC5)), four apoptosis-related genes (heat shock 27-kDa protein 1 (HSPB1), zinc finger protein 480 (ZNF480), tubulin alpha 1c (TUBA1C), and ribosomal protein L30 (RPL30)), and three metabolism-related genes (aldolase B (ALDOB), frequently rearranged in advanced T-cell lymphomas 2 (FRAT2), and tRNA methyltransferase 1 (TRMT1)).
In addition, ETS1 also induces both metabolism through the mediation of TRMT1 and apoptosis through the mediation of ZNF480 (see Figure 3).
Furthermore, we found seven genes in NAFLD&NASH pathogenesis and NAFLD&NASH-associated hepatocarcinogenesis that also played a central role in PBC&PSC pathogenesis and PBC&PSC-associated hepatocarcinogenesis, i.e., two DNA repair-related genes (HIST2H2BE and RFC5), two apoptosis-related genes (ZNF480 and RPL30), and three metabolism-related genes (ALDOB, FRAT2, and TRMT1).