MEFV

(redirected from TRIM20)

MEFV

A gene on chromosome 16p13.3 of the RetRo gene family that encodes pyrin or marenostrin, an important modulator of innate immunity, which is thought to control the inflammatory response in myelomonocytic cells at the level of the cytoskeleton.

Molecular pathology
Defects in MEFV cause Familial Mediterranean fever, both the autosomal dominant and autosomal recessive forms.
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