TERF2

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TERF2

A gene on chromosome 8q21.11 that encodes a protein which is an integral component of the telomere nucleoprotein complex. It is present at telomeres during metaphase of the cell cycle and inhibits telomerase, acting in cis to limit elongation of chromosome termini; TERF2 differs from TERF1 in that its N terminus is basic, while TERF1 is acidic.
References in periodicals archive ?
Viewed under an electron microscope, telomeres exposed to TRF2 often displayed large circles, which the researchers named t loops, but no single-stranded ends.
Cells lacking TRF2 activate DNA-repair machinery and sometimes even commit suicide, suggesting that telomeres require TRF2 to form loops, says de Lange.
Unipex Innovations; and "Role of TRF2 in Preventing Cellular Senescence and Associated Skin Damages,"Isabellc Imbert, Ph.