TERF2

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TERF2

A gene on chromosome 8q21.11 that encodes a protein which is an integral component of the telomere nucleoprotein complex. It is present at telomeres during metaphase of the cell cycle and inhibits telomerase, acting in cis to limit elongation of chromosome termini; TERF2 differs from TERF1 in that its N terminus is basic, while TERF1 is acidic.
References in periodicals archive ?
It has been shown in mice that conditional deletion of Trf1 or Trf2 in type 2 alveolar epithelial cells leads to a significant telomere damage response, cellular senescence, and a pulmonary fibrosis phenotype, while maintaining normal telomere length [5, 32].
This involves activation of ATM, which is normally suppressed by TRF2 and/or activation of ATR which is normally suppressed by POT1 [43].
Because TRF2 and GAPDH are both involved in the regulation of telomere homeostasis, the aim of this study was to determine if there was a correlation between the expression of these genes in primary cell cultures of ovarian surface epithelium, using qRT-PCR.
Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia.
Step 3 : (trf1*trf1) [right arrow] [freel1] [right arrow] (trf2) [right arrow] [freel2] [right arrow] [*trf1@]
The investigators synthesized telomeric DNA and mixed it with TRF1 or TRF2. Viewed under an electron microscope, telomeres exposed to TRF2 often displayed large circles, which the researchers named t loops, but no single-stranded ends.
They are telomere repeat-binding factor 1 (TRF1), telomere repeat-binding factor 2 (TRF2), repressor-activator protein 1 (RAP1), TRF1- and TRF2-interacting nuclear protein 2 (TIN2), tripeptidyl-peptidase 1 (TPP1), and protection of telomere 1 (POT1) [35].
Unipex Innovations; and "Role of TRF2 in Preventing Cellular Senescence and Associated Skin Damages,"Isabellc Imbert, Ph.D., J.M.
. Curso de Direito Avancado de Direito Privado, EMARF, TRF2: ACOES POSSESSORIAS (caso Jardim Botanico) E USUCAPIAO DE BENS PUBLICOS; Palestrantes: Poul Erik Dyrlund e Miriam Fontenelle; em 29 de Junho de 2009;
De Lange, "p53and ATM-dependent apoptosis induced by telomeres lacking TRF2," Science, vol.