TERF1

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TERF1

A gene on chromosome 8q21.11 that encodes a protein which is an integral component of the telomere nucleoprotein complex. It is present at telomeres throughout the cell cycle and inhibits telomerase, acting in cis to limit elongation of chromosome termini.
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A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins," Science, vol.
To investigate the connection between telomeres and pluripotency, researchers generated a 'reporter' mouse: they linked together the TRF1 gene and the gene coding for a green fluorescent protein and created a lineage of mice carrying this new genetic bag gage.
They discovered that TRF1 is an excellent marker for stem cells, both in adult stem cells--those that arc found in tissues and die different organs of the body--and embryonic stem cells, ft is also the case with 'induced pluripotent' stem cells (iPS cells), which arc pluripotent cells that come from artificially reprogrammed specialized cells.
APPENDIX Variable Definitions TRF Annualized aggregate tariff rates TRFPC Precommitment (PC) announced tariffs TRF1 One-period lag of tariff ICTRF1 Ivory Coast lagged tariff KNTRF1 Kenya lagged tariff MLTRF1 Mali lagged tariff MWTRF1 Malawi lagged tariff NGTRF1 Nigeria lagged tariff SNTRF1 Senegal lagged tariff TZTRF1 Tanzania lagged tariff ICPC Ivory Coast PC tariff KNPC Kenya PC tariff MLPC Mali PC tariff MWPC Malawi PC tariff NGPC Nigeria PC tariff SNPC Senegal PC tariff TZPC Tanzania PC tariff CAC Ratio of current account deficit to GDP CFA Dummy variable = 1 if country belongs to CFA zone, 0 otherwise
During such searches, Titia de Lange of the Rockefeller University in New York and her colleagues did identify two proteins, TRF1 and TRF2, that bind to the double-stranded portion of mammalian telomeres.