It has been shown in mice that conditional deletion of Trf1 or Trf2 in type 2 alveolar epithelial cells leads to a significant telomere damage response, cellular senescence, and a pulmonary fibrosis phenotype, while maintaining normal telomere length [5, 32].
van Overbeek et al., "A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins," Science, vol.
To investigate the connection between telomeres and pluripotency, researchers generated a 'reporter' mouse: they linked together the TRF1 gene and the gene coding for a green fluorescent protein and created a lineage of mice carrying this new genetic bag gage.
They discovered that TRF1 is an excellent marker for stem cells, both in adult stem cells--those that arc found in tissues and die different organs of the body--and embryonic stem cells, ft is also the case with 'induced pluripotent' stem cells (iPS cells), which arc pluripotent cells that come from artificially reprogrammed specialized cells.
During such searches, Titia de Lange of the Rockefeller University in New York and her colleagues did identify two proteins, TRF1 and TRF2, that bind to the double-stranded portion of mammalian telomeres.
The investigators synthesized telomeric DNA and mixed it with TRF1 or TRF2.
jurisprudence of the Federal Regional Court of the 1st Region, AC 2005.35.00.001301-1/GO, TRF1
Case Law Bulletin no 105, Session from 08/09/2010 to 08/13 / 2010 Third Class; 2008.33.00 AC.
The examination of genes hTERT, TRF1
, TRF2, TIN2, RAP1, POT1, and TTP1 indicated that SHS-treated eMSC express only two genes (POT1 and TTP1) providing telomere protection.
They are telomere repeat-binding factor 1 (TRF1
), telomere repeat-binding factor 2 (TRF2), repressor-activator protein 1 (RAP1), TRF1- and TRF2-interacting nuclear protein 2 (TIN2), tripeptidyl-peptidase 1 (TPP1), and protection of telomere 1 (POT1) .
Studies show there was different expression in cervical cancer and stomach cancer of telomere repeat binding factors 1 and 2 (TRF1
and TRF2), which maintained the stability of telomere.
Proteins comprising the Shelterin complex are TRF1
, TRF2, TIN2, RAP1, TPP1, and POT1.