miRNA: micro-RNA RISC: RNA-induced silencing complex Ago2: Argonaut 2 TRBP
: Human immunodeficiency virus transactivating response RNA-binding protein IL: Interleukins RANKL: Receptor activator of nuclear factor kappa-B ligand TLR: Toll-like receptors TNF-[alpha]: Tumor necrosis factor alpha MMP: Matrix metalloproteinases CCL2: Chemokine ligand 2 CDK2: Cyclin-dependent kinase 2 Cyr61: Cysteine-rich angiogenic inducer 61 TNFAIP3: Tumor necrosis factor alpha-induced protein 3 BCL2: B cell lymphoma 2 M-CSF: Macrophage colony-stimulating factor IKK-[alpha]: Inhibitor of nuclear factor kappa-B kinase subunit alpha PADI4: Peptidylarginine deiminase 4 gene Tregs: Regulatory T cells PTPN22: Protein tyrosine phosphatase, nonreceptor type 22 gene.
On the other hand, some fluoroquinolone antibiotics, as enoxacin, have been described to enhance the effect of siRNAs or miRNAs by increasing the binding affinity of TRBP to the miRNA precursors.
Dysregulation of miRNA biogenesis machinery is also frequent in cancer mainly due to mutations in one or several of the proteins involved in processing (Drosha, DGCR8, DICER, TRBP, and Argonaute), or in nuclear export (exportin 5), or by alterations in their posttranslational modifications (PTMs) [7, 9-14].
 Nonstandard abbreviations: miRNA, microRNA; pri-miRNA, primary miRNA transcripts; pre-miRNA, precursor miRNA; TAR, trans-activation response; TRBP
, TAR binding protein; RISC, RNA- induced silencing complex; AGO-2, Argonaute protein; nSMase2, neutral sphingomyelinase 2; FFPE, formalin-fixed paraffin-embedded; CSF, cerebrospinal fluid; qPCR, quantitative PCR; AMI.
Good Faith Deposits of all Qualified Bidders shall be held in a separate interest-bearing account for the Debtor's benefit until the earlier of (a) August 12, 2010 or (b) consummation of a transaction involving any other Qualified Bidder for the TRBP Assets.
The Debtor reserves the right to (i) withdraw its offer to sell the TRBP Assets at any time subsequent to the Auction, subject to payment of the Stalking Horse Protections if then due pursuant to the Bidding Procedures Order, and (ii) reject any or all bids other than the Stalking Horse Bid if, in the CRO's reasonable business judgment, in consultation with the Debtor, such other bids are not for a fair and adequate price.
What is unclear is whether these changes will allow the third class, TRBP
Equity Interest, to then have its impairment lifted.
The Ad Hoc Group of First Lien Lenders (collectively, the "Lenders") in the Texas Rangers Baseball Partners ("TRBP
") bankruptcy matter today issued the following statement in connection with today's Court ruling:
However, unless the treatment of the Lenders is modified, the Plan (as modified to date) will not be confirmable absent acceptance by the Lenders, the only class of creditors that is impaired under the present iteration of the Plan," he left the window open for TRBP
to amend the Plan to address the needs of the Lenders, and setting up a situation where veto power could be revoked.
The judge overseeing the voluntary bankruptcy proceedings of the Texas Rangers has ruled in favor of the disclosure statement filed by Texas Rangers Baseball Partners and has set a July 9 confirmation date that could approve a Prepackaged Plan filed by TRBP
that would move them out of Chapter 11 status.
The case will be made by lawyers for TRBP
that 12 Classes of Claims are "unimpaired" and therefore, the creditors have no voting rights to block the sale to the Greenber/Ryan group.
Bankruptcy Judge Michael Lynn will hear arguments on the "pre-packaged plan", that would allow for the Rangers to emerge from voluntary Chapter 11 bankruptcy with July 9th being the possible date that Lynn could rule to allow the transfer of the Rangers ownership to occur between HSG and TRBP
, or whether the process is opened back up, thus allowing for Jim Crane to engage in the bidding process.