TRAF2

(redirected from TRAP3)

TRAF2

A gene on chromosome 9q34 that encodes TNF receptor-associated factor 2, an adapter molecule which regulates NF-kappaB and JNK activation and plays a role in regulating cell survival and apoptosis. TRAF2 is required for normal antibody isotype switching from IgM to IgG. It has E3 ubiquitin-protein ligase activity and promotes Lys-63-linked ubiquitination of target proteins (e.g., BIRC3, RIPK1 and TICAM1).
References in periodicals archive ?
The up-regulated genes include HIAP1, CRAF1, TRAF6, CASP1, CASP2, CASP3, CASP4, HPRT, GADD45, MCL-1, NIP1, BCL2L2, TRAP3, GSTP1, DAXX, PIG11, UBC, PIG3, PCNA, CDC10, JNK1 and RBP2.