TRAF6


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TRAF6

A gene on chromosome 11p12 that encodes an E3 ubiquitin ligase which, together with UBE2N and UBE2V1, synthesises Lys-63-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. It also ubiquitinates a free/unanchored polyubiquitin chain, leading to MAP3K7 activation, and activates NF-kappaB and JUN. It may be essential for forming functional osteoclasts and is thought to play a role in dendritic cell maturation and/or activation. It represses c-Myb-mediated transactivation of B cells. It acts as an adapter protein for signal transduction by TNF receptor, as well as IL-1 and IL-17 receptors. It is expressed in the heart, brain, placenta, lungs, liver, skeletal muscle, kidneys and pancreas.
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In MyD88-dependent pathway, there is the recruitment and activation of IRAKs and TRAF6, inducing TAK1 activation.
Bacterial lipopolysaccharides and RANKL induce human peripheral blood mononuclear cells to express A20, which is associated with TRAF6 and NF-kB degradation.
Then, TGFBR2, CDKN1B, KRAS, E2F3, TRAF6, and CHUK were also selected as our target molecules.
(2006) Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439, 204-207.
Primers for the TLR4, MyD88, TRAF6, and NF-KB, IL-1b, IL-6 and b-actin genes were designed using Premier 6.0 (Premier Biosoft International, USA).
Zhang et al., "Attenuation of cardiac dysfunction in polymicrobial sepsis by MicroRNA-146a is mediated via targeting of IRAK1 and TRAF6 expression," Journal of Immunology, vol.
Interaction between RANK and RANKL leads to the recruitment of TNF receptor-associated factor 6 (TRAF6) and the subsequent activation of several downstream signalling pathways including nuclear factor-kB (NF-[kappa]B) as well as the p38 mitogen-activated protein kinase (MAPK), c-Jun-N-terminal kinase QNK), extracellular signal-regulated kinase (ERIC) and PI3K/AKT signalling pathways (Wei et al.
Upon TLR activation, MyD88 recruits interleukin 1 receptor associated kinase 4 (IRAK-4) that phosphorylates IRAK1 which in turn activate TNF Receptor-Associated Factor 6 (TRAF6).
The research complements an article published just last week that describes the role of another protein, TRAF6 (TNF receptor-associated factor 6), in ensuring the vitality of the satellite stem cells.
Transcripts included TNF receptor-associated factor 6 (Traf6), which is a unique member of the TNF receptorassociated factor family that signals through the IL-1 receptor and TLR superfamily and is not activated by the TNF receptor.
De manera similar, en la EM, la interaccion IL-17/IL-17R utiliza a TRAF6 para traducir su senal en celulas inmunes.
TRAF2, -5, and -6 all bind to RANK, but of these only TRAF6 appears to be essential in osteoclasts formation.