In MyD88-dependent pathway, there is the recruitment and activation of IRAKs and TRAF6
, inducing TAK1 activation.
Bacterial lipopolysaccharides and RANKL induce human peripheral blood mononuclear cells to express A20, which is associated with TRAF6
and NF-kB degradation.
Then, TGFBR2, CDKN1B, KRAS, E2F3, TRAF6
, and CHUK were also selected as our target molecules.
(2006) Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
. Nature 439, 204-207.
Primers for the TLR4, MyD88, TRAF6
, and NF-KB, IL-1b, IL-6 and b-actin genes were designed using Premier 6.0 (Premier Biosoft International, USA).
Zhang et al., "Attenuation of cardiac dysfunction in polymicrobial sepsis by MicroRNA-146a is mediated via targeting of IRAK1 and TRAF6
expression," Journal of Immunology, vol.
Interaction between RANK and RANKL leads to the recruitment of TNF receptor-associated factor 6 (TRAF6
) and the subsequent activation of several downstream signalling pathways including nuclear factor-kB (NF-[kappa]B) as well as the p38 mitogen-activated protein kinase (MAPK), c-Jun-N-terminal kinase QNK), extracellular signal-regulated kinase (ERIC) and PI3K/AKT signalling pathways (Wei et al.
Upon TLR activation, MyD88 recruits interleukin 1 receptor associated kinase 4 (IRAK-4) that phosphorylates IRAK1 which in turn activate TNF Receptor-Associated Factor 6 (TRAF6
The research complements an article published just last week that describes the role of another protein, TRAF6
(TNF receptor-associated factor 6), in ensuring the vitality of the satellite stem cells.
Transcripts included TNF receptor-associated factor 6 (Traf6
), which is a unique member of the TNF receptorassociated factor family that signals through the IL-1 receptor and TLR superfamily and is not activated by the TNF receptor.
De manera similar, en la EM, la interaccion IL-17/IL-17R utiliza a TRAF6
para traducir su senal en celulas inmunes.
TRAF2, -5, and -6 all bind to RANK, but of these only TRAF6
appears to be essential in osteoclasts formation.