TRAF5


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TRAF5

A gene on chromosome 1q32 that encodes TNF receptor-associated factor 5, an adapter protein and signal transducer which links members of the tumour necrosis factor receptor family to various signalling pathways, including that of apoptosis, by associating with the receptor cytoplasmic domain and kinases. TRAF5 activates NF-kappaB and probably JNK. It is expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes.
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Remarkably, TRAF6 is uniquely pleiotropic in participating in the signal transduction of many receptor systems while TRAF2, TRAF3, and TRAF5 appear to signal only within the TNF receptor superfamily [23].
Importantly, the methylation statuses of 43 overlapping DMPs in CpG islands and 72 DMPs in the CpG island-surrounding regions were significantly different across the three AIDs and many vital proinflammatory genes were included [25-28] such as IL6R, IFNGR1, STAT3, PSMB9, PSMB8, TNFRSF12, TNFRSF1A, TNFSF12TNFSF13, CD164, and TRAF5 (Figures 2(d) and 2(e)).
The cytoplasmic domain of Fn14 contains a phylogenetically conserved binding motif, and TRAF1, TRAF2, TRAF3, and TRAF5 are able to bind to this site [3].