TRAF2


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TRAF2

A gene on chromosome 9q34 that encodes TNF receptor-associated factor 2, an adapter molecule which regulates NF-kappaB and JNK activation and plays a role in regulating cell survival and apoptosis. TRAF2 is required for normal antibody isotype switching from IgM to IgG. It has E3 ubiquitin-protein ligase activity and promotes Lys-63-linked ubiquitination of target proteins (e.g., BIRC3, RIPK1 and TICAM1).
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References in periodicals archive ?
The protein and mRNA levels of TRAF2 and the phosphorylation of JNK were markedly increased in the ConA group, and OA reduced the expression levels of TRAF2 and the activation of JNK (Figures 5(a)--5(c)).
Ahmed, "MicroRNA-17 suppresses TNF-[alpha] signaling by interfering with TRAF2 and cIAP2 association in rheumatoid arthritis synovial fibroblasts," The Journal of Immunology, vol.
Exton, "Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1[alpha]-mediated NF-[kappa]B activation and down-regulation of TRAF2 expression," Molecular & Cellular Biology, vol.
Using the data from macrophages and fibroblasts, PathGen linked IL-27 to regulation of IL1[beta], TNF, and IL-6 through the IL12a and NF-[kappa]B/Rel pathways and to TRAF2 potentially through MDFI.
In addition, FBX07 binds to, and mediates ubiquitin conjugation to cIAP1 (cellular inhibitor of apoptosis protein 1) and TRAF2 (TNF receptor-associated factor 2), which leads to lowered activity of NF-[kappa]B (nuclear factor [kappa]B) (Kuiken et al., 2012).
At the same time, TNFR1 starts its own signaling associated with the RIP1-TRADD-TRAF2 complex, formed by the associated death domain receptor of TNF-R1 (TRADD), protein-1 that interacts with the receptor (RIP1), and factor 2 associated with TNF-R1 (TRAF2).
Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15R-alpha chain.
Binding to TNF-R1 activates apoptotic and necrotic pathways through a signaling cascade involving multiple proteins, including TNF-R1-associated death domain protein (TRADD); TNF receptor-associated factor 2 (TRAF2); and caspases 8, 3, and 7.
p43 could recruit signaling proteins, such as TRAF2 and RIP1, and activates the NF-kB pathway (Kataoka & Tschopp, 2004).
La activacion de TNFR1 resulta del reclutamiento de la proteina TRADD con la asociacion de las proteinas TRAF2 (factor 2 asociado a la proteina receptora de TNF[alfa]) o con FADD (proteina adaptadora que contiene un dominio de muerte citosolico); TRAF2 media la activacion de NF[kappa]B, mientras que FADD interactua con pro-caspasa 8, activandola.
TRAF2, -5, and -6 all bind to RANK, but of these only TRAF6 appears to be essential in osteoclasts formation.