TRAF1


Also found in: Acronyms.

TRAF1

A gene on chromosome 9q33-q34 that encodes TNF-receptor-associated factor 1, an adapter molecule which regulates NF-kappaB and JNK activation and plays a role in regulating cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that ubiquitinates target proteins, such as MAP3K14, and recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
Mentioned in ?
References in periodicals archive ?
Primary antibodies against TRAF1 and Bcl-xL were purchased from Cell Signaling Technology (Beverly, MA, USA).
pylori virulence factors and TRAF1, 4-1BB, and BclxL expression, the number of samples positive or negative for cagA, vacAs1, and vacAm1 was stratified according to TRAF1, 4-1BB, and Bcl-xL expression (Table 2).
pylori may promote the IM and Ca pathogenesis, possibly by upregulating TRAF1, 4-1BB, and Bcl-xL expression in the gastric mucosal tissue.
Molecules, such as APOB, ATM, MIA3, MICAL2, REST, TRAF1, UTP18, TRAPPC8, CCDC88A, and SNAPC1 in the network were shown to bind directly to UBC (ubiquitin C) by proteomic analyses of ubiquitylated proteomes [12-15], suggesting that the various cellular functions including protein degradation by ubiquitylation may play a role for the expression of muscle color in chickens though the specific roles of each factor in regulating muscle color development need further investigations.
Key findings of this study included the upregulation of the IRF1, IL-6 and the TNF adapter protein TNFSF10 as well as the TNF receptor family members TRADD and TRAF1 and the other known inflammation-related transcripts such as PTGS2, BCL2, and CCND1 on LPS stimulation.
The Human Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 Gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-KB and c-Jun N-terminal kinase.
Although there is substantial evidence that TRAF1 and C5 may both be effective in the proliferation of inflammatory responses, functional studies will be required to further investigate the TRAF1/C5 association (45).
NF-[kappa]B antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and cIAP2 to suppress caspase-8 activation.
Characterization of LMP-1's association with TRAF1, TRAF2, and TRAF3.
Recent studies with gene expression array analysis (4,5) demonstrated a molecular signature in PMBCL that was different from that of other DLBCLs, particularly the expression levels in JAK2, TRAF1, MAL, REL, and PDL2.
(96,156) Approximately 65% to 80% of C-ALCLs, LyPs, transformed MFs, and cases of secondary skin involvement in systemic ALK- ALCL express TRAF1 and 70% to 100% express MUM1; therefore, these antigens have limited usefulness in distinguishing CALCL from LyP or systemic disease.
In addition, compared to primary cutaneous PTCL-NOS, C-ALCL had high expression of IRF4/MUM1, TNFRSF8/CD30, and TRAF1, involved in regulation of apoptosis, and decreased expression of CDKN2C/p18.