thrombopoietin

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thrombopoietin

 [throm″bo-poi´ĕ-tin]
a colony-stimulating factor that is the humoral regulator of the production of platelets.

throm·bo·poi·e·tin

(throm'bō-poy'ĕ-tin), [MIM*600044]
A cytokine that serves as a humoral regulator for the production of blood platelets through action on the receptor c-mp1.
[thrombo- + G. poiētēs, maker, + in]

throm·bo·poi·e·tin

(throm'bō-poy'ĕ-tin)
A cytokine that serves as a humoral regulator for the production of blood platelets through action on the receptor c-mp1.
Synonym(s): megakaryocyte growth and development factor, megapoietin.
[thrombo- + G. poiētēs, maker, + in]

thrombopoietin

A hormone responsible for the growth of colonies of megakaryocytes and the production of platelets. The existence of thrombopoietin has been suspected for 30 years but was realized only in 1994. In 1997 the results of a trial of polyethylene-conjugated genetically-engineered (recombinant) thrombopoietin-described as recombinant human megakatyocyte growth and development factor (PEGrHuMGDF)-was published. It was found to have a powerful stimulatory effect on PLATELET production. Thrombopoietin is the ligand for the cytokine receptor Mpl.

thrombopoietin

an α2-globulin, a hormone involved in the differentiation and maturation of platelets but thought to be responsible for regulating the supply of platelets.
References in periodicals archive ?
Rubin adds that market and investor pressures, such as the increase in capital requirements, also make life more difficult for those trying to make their way in the TPO channels (especially correspondent).
Dow Automotive R&D also reported on its At-Press TPO blending system, which allows a route to both cost savings and flexibility to alter shrinkage, CLTE, stiffness, toughness, and heat resistance.
ViChem's "Spectra fascia grades have enhanced low-temperature ductility to meet or exceed the performance of painted TPO fascia.
Using these parameters, pressure profiles from the mold filling simulations were compared with those from experimerits in the instrumented slot mold for nonfoamed LDPE and TPO melts.
However, according to Ms Unarkat, a TPO on a site does not necessarily mean the end to development.
Under oxidative conditions, TPO catalyzes the coupling of iodotyrosines to iodothyronine residue in Tg.
The choice of polymer utilized in the primer, most often a chlorinated poly(olefin), is also of utmost importance in attempting to attain robust adhesion to the TPO substrate.
Ken, 40, of Chapel Park, Newcastle, has worked on TPOs for 14 years, with the last seven on this service, TPO Midland.
Currently, the Lavergne Performance Compounds (LPC) division of the company offers engineering resin lines of recycled fiberglass/ mineral filled PET, virgin and recycled polypropylene compounds, paintable virgin thermoplastic olefins (TPO), recycled TPO, recycled polycarbonate and thermoplastic elastomers.
In a report to the Arfon Planning committee, planning manager Hywel Thomas said several mature trees were protected by the TPO because of their contribution to the landscape and amenity of this area of the town.
We would like to share our experience regarding the interactions of IL-6, IL-1[beta], and TPO in pathologic thrombopoiesis.
It is generally accepted that regulation of circulating TPO occurs mainly through TPO binding to megakaryocyte mpl (5, 6).