thiopurine s-methyltransferase

(redirected from TPMT)
Also found in: Acronyms.

thiopurine s-methyltransferase

(thī″ŏ-pūr′ēn″es′meth″ĭl-trans′fĕr-ās″),

TPMT

An enzyme that metabolizes and inactivates thiopurines (such as the drugs azathioprine and mercaptopurine). People with a genetic deficiency in TPMT have severe bone marrow suppression when they take thiopurines to manage diseases such as rheumatoid arthritis or inflammatory bowel disease.
References in periodicals archive ?
For her part TPMT member Karen Tanada, of the Gaston Z.
This debate is followed by a discussion of the IHH's broadening nongovernmental humanitarian mission through humanitarian diplomacy and mediation, which is followed by an exclusive analysis of the IHH's mediator role in the TPMT and MILF's disarmament.
Molecular Biology schemes: Factor V-Leiden, prothrombin, MTHFR, PAII (SERPINE1), factor XIII (F13A1), GPIIIa (1TGB3), [3Fib (FGB), VKORC1, Factor XII (F12), a1 PI, APOE, APOB, ACE, CETP, TPMT, CYP2C19, CYP2D6, CYP2C8, CYP2C9, UGT1A1 , DPD (DPYD), BCHE, ALDOB, HFE, LCT, NOD2, ATP7B, FSAP (HABP2), ITGA2, KRAS.
The patient had an unusual and extremely high thiopurine 5- methyltransferase (TPMT) activity in erythrocytes [61.5 nmol x [h.sup.-1] x [(mL erythrocytes).sup.-1;] reference interval, 8.5-15 nmol x [h.sup.-1] x [(mL erythrocytes).sup.-1]].
The statement said the parties achieved "a milestone with the signing of the Terms of Reference for the Third Party Monitoring Team (TPMT), the body that will review, assess, evaluate and monitor the implementation of the Framework Agreement on the Bangsamoro (FAB) and its Annexes."
Gene Variants TPMT p.Ala80Pro, p.Ala54Tyr, p.Tyr240Cys GSTT1 Large deletion GSTM1 Large deletion GSTP1 p.Ile105Val MTHFR p.Ala222Val, p.Glu429Ala GGH p.ttr151Ile TMPT: thiopurine methyltransferase; GST: glutathione-S-transferase family; MTHFR: methylenetetrahydrofolate reductase; GGH: gamma-glutamyl hydrolase.
Botto, "Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine," Rheumatology, vol.
In general, the optimum dosage is 2.5 to 3.5 mg/kg/day of azathioprine; however, if an intermediate level of the erythrocyte thiopurine methyltransferase (TPMT) enzyme is obtained (see the discussion of monitoring, below), that dosage can be adjusted downward to 1 mg/kg/day.
This particularly applies to drugs with narrow therapeutic indices, and several notable examples are presented by cytostatics, oral anticoagulants and antiarrhythmics metabolised by the polymorphic enzymes thiopurine S-methyltransferase (TPMT), cytochrome P450 (CYP) 2C9 and CYP2D6.
1 February 2012 - US biomedical company Biomerica Inc (OTCBB:BMRA) said on Tuesday it had released a new patented Thiopurine methyltransferase (TPMT) test to identify individuals who are at risk of developing severe or fatal side effects after treatment with thiopurine drugs.
Activity of two enzymes: thiopurine s-methyltransferase (TPMT), a highly polymorphic enzyme, and xanthine oxidase (XO), produces inactive metabolites.