TP53


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TP53

(tē′pē′fĭf′tē-thrē′)
n.
See p53.
References in periodicals archive ?
Our lab at the University of Utah studies the broken DNA damage response in people with Li-Fraumeni Syndrome who are missing their TP53 genes and have a very high rate of cancer.
ddPCR probes matching the TP53 mutations found in tumor tissue were purchased from Bio-Rad: some of the probes were already available with in vitro experiments supporting the claimed sensitivity or with in silico optimization; the remaining probes were custom-designed (see online Supplemental Table 2).
In contrast to TP53 mutations, the adverse effect of RAS mutations on survival and risk of relapse was evident only in reduced-intensity conditioning.
The tumor suppressor TP53 is one of the most frequently downregulated proteins in cancers, and many p53 mutants are oncogenic [18].
The frequency of mutations lacking 17p13 deletion is variable, but in general they represent 30% of all TP53 defects, whereas sole 17p13 deletion with the absence of TP53 mutation is less frequent (10% of all TP53 defects) [3].
In summary, we presented a very rare case of gastric medullary carcinoma with sporadic mismatch repair deficiency for MLH1 and PMS2, wild-type BRAF gene, and a TP53 c.817C>T (p.R273C) gene mutation.
The advanced pathological grade was significantly associated with strong expression of Ki67 (p = 0.001), TgFb1 (p = 0.034), VEGFA proteins (p = 0.001), and absent Tp53 staining (p = 0.029) (Figures 7(a), 7(b), 7(c), and 7(d)).
In this study, the effects of dioscin on tumor growth, cell proliferation and apoptosis were investigated as well as the potential involvement of p53 (TP53), BCL2-associated X protein (BAX), B-Cell CLL/Lymphoma 2 (BCL2) and Caspase 3 (CASP3) signaling pathway.
Several studies have reported combined mutations in K-Ras and TP53 genes in CRC tumours, [7] but the clinical usefulness of K-ras and/or TP53 gene mutations is still somewhat controversial.
Results: The results showed that mutated TP53 in MDA-MB-468 cells interacted with BRCA1 protein in vivo and did not effect WT TP53 binding to this protein in vitro.
The Arg72Pro polymorphism of TP53 gene was analyzed by PCR using the 72A and 72S primers described by Lin et al.
Detection of somatic TP53 mutations in tampons of patients with high-grade serous ovarian cancer [published online ahead of print October 2014], Obstet Gynecol.