CDKN2B

(redirected from TP15)

CDKN2B

A gene on chromosome 9p21 that encodes a member of the INK4 family of cyclin-dependent kinase inhibitors, which form a complex with CDK4 or CDK6, preventing activation of CDK kinases and thus acting as cell growth regulators by controlling cell cycle progression through G1. CDKN2B expression is dramatically induced by TGF beta, suggesting a role in TGF-beta-induced growth inhibition.
References in periodicals archive ?
The Vitros Syphilis TPA assay is a qualitative assay that detects total antibodies (IgG, IgM and IgA) to recombinant Treponema pallidum (TP) antigens TP15, TP17, TP47.
In this set the 15kDa lipoprotein (Tp15; tp0171 gene product) and the major outer membrane 17kDa lipoprotein (Tp17; tp0435 gene product) are the key members [22].
Sample TPHA Immulite RPR IgG-FTA 2000 CIA -ABS 1 1:160 Neg Neg Neg 2 1:160 Neg Neg Neg 3 1:320 Neg Neg Neg 4 Neg Pos Neg 1:20 5 Neg Pos Neg 1:10 6 Neg Pos Neg 1:20 7 Neg Pos Neg 1:20 8 Neg Pos Neg Neg 9 Neg Pos Neg Neg 10 Neg Pos Neg Neg Sample IgM-FTA Captia IgG-Inno-LIA -ABS IgM-EIA 1 Neg / Neg (Tp47/Tp17/Tp15/TmpA 0) 2 Neg / Neg (Tp47/Tp17/Tp15/TmpA 0) 3 Neg / Neg (Tp47/Tp17/Tp15/TmpA 0) 4 Neg / Pos (Tp47/Tp17 1+, Tp15/TmpA 0) 5 Neg Neg Pos (Tp47/Tp17 1+, Tp15/TmpA 0) 6 Neg Neg ID (Tp47/Tp15/TmpA 0, Tp17 2+) 7 Neg Neg Pos (Tp17/TmpA 2+, Tp15 0.5+, Tp47 0) 8 Neg Neg Neg (Tp47/Tp15/TmpA neg/Tp17 0.5+) 9 Neg Neg Neg (Tp47/Tp15/TmpA neg/Tp17 0.5+) 10 Neg / Neg (Tp47/Tp17/Tp15/TmpA neg)
The position of Tp47, Tp17 and Tp15 in the WB native Tp was previously verified in reaction performed with affinity purified monospecific antibodies.