TNP-470

TNP-470

An angiogenesis inhibitor used in the treatment of cancer to reduce blood vessel formation in tumors.
References in periodicals archive ?
Kuebler et al., "Antimicrosporidial activities of fumagillin, TNP-470, ovalicin, and ovalicin derivatives in vitro and in vivo," Antimicrobial Agents and Chemotherapy, vol.
The angiogenesis inhibitors TNP-470, endostatin, and anginex inhibited the number of endometriosis lesions present in a mice model [70].
Her paper, "Angiogenesis Inhibitors Endostatin or TNP-470 Reduce Intimal Neovascularization and Plaque Growth in Apolipoprotein e-Deficient Mice," showed that the growth of the small blood vessel network feeding coronary artery plaques in mice could be reduced by giving them an angiogenesis inhibitor.
Ten received a protein called endostatin, and 15 got a synthetic compound called TNP-470. Twelve other mice received inert injections.
However, the mice getting TNP-470 showed a more modest 60 percent increase, while those given endostatin experienced plaque growth of only 28 percent, says study coauthor Karen S.