LTBR

(redirected from TNFRSF3)

LTBR

A gene on chromosome 12p13 that encodes lymphotoxin beta receptor, which belongs to the tumour-necrosis-factor-receptor superfamily and is expressed on the surface of most cell types (e.g., epithelial and myeloid lineages), but not on T or B cells. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta) and, with its ligand, plays a role in the development and organisation of lymphoid tissue and transformed cells. LTBR activation can trigger apoptosis; it associates with TRAF3, TRAF4 and TRAF5.
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LIGHT (lymphotoxin-like inducible protein that competes with glycoprotein D for binding herpesvirus entry mediator on T cell, TNFSF14), ligand for the lymphotoxin beta receptor (LT[beta]R, TNFRSF3), and the herpesvirus entry mediator (HVEM; TNFRSF14) are expressed mostly on activated T cells, although they were found also on monocytes, granulocytes, and immature dendritic cells [173, 174].